65岁以上中晚期老年女性乳腺癌新辅助内分泌治疗28例疗效观察

目的:探讨65岁以上中晚期老年女性乳腺癌术前新辅助内分泌治疗的近期疗效。方法:28例老年女性乳腺癌患者术前服用芳香化酶抑制剂来曲唑:2.5mg/次,1次/日观察疗效,治疗6～9个月后进行手术。结果:本组患者术前内分泌治疗无完全缓解病例,部分缓解8例(28.57%),轻度缓解12例(42.86%),无变化5例(17.86%),无效3例(10.71%)。结论:来曲唑在65岁以上老年中晚期乳腺癌新辅助内分泌治疗显效良好,不良反应轻微。

28 cases of efficacy observation on over-65-year-old women with breast cancer by neoadjuvant endocrine therapy

Objective: To investigate the curative effect of neoadjuvant endocrine therapy for the mid and late female breast cancer patients over 65 years old.Methods: 28 cases of elderly female breast cancer patients take the aromatase inhibitor letrozole:25mg Po qd.Then an observation of effect is given and a surgery is operated after treatment of 6 to 9 months.Results: Of 28 cases in the treatment group,none showed complete remission,8(28.57%) cases showed partial remission,12(42.86%) cases showed mild remission,5(17.86%) cases showed stable disease,3(10.71%) cases showed progress disease.Conclusion: letrozole has better efficacy but low adverse reaction of neoadjuvant endocrine therapy for the mid and late female breast cancer patients over 65 years old.