聚焦超声和射频消融治疗宫颈炎症相关疾病的临床随机对照研究

目的比较聚焦超声和射频消融治疗宫颈炎症相关疾病的有效性、安全性、经济性。方法采用临床随机对照研究，超声组与射频组患者各100例，观察两组术后疗效、不良反应以及临床干预阴道出血所需费用。结果总有效率：超声组98．89％（89／90）；射频组98．90％（90／91，x2〈O．001，P=0．99）。不良反应：射频组术后阴道出血需要临床干预的百分率（21／96，21．88％）高于超声组（9／95，9．47％，X2=5．55;P=0．02），其中因急性感染而出血的百分率射频组（16／21，76．19％）高于超声组（3／9，33．33％，P-0．04）。阴道出血临床干预费用中，检查费、处置费两组差异无统计学意义（Z=-0．02、-0．61，P均〉0．05），药物费、总费用两组差异有统计学意义（Z=-4．39、-3．87，P均〈0．05）。结论聚焦超声对宫颈炎症相关疾病的疗效与射频治疗相当，但术后不良反应及对不良反应阴道出血的干预费用明显低于射频治疗。

Randomized control study on focused ultrasound and radiofrequency ablation in treatment of cervical inflammation related diseases

Objective To compare the clinical efficacy, safety, economy between focused ultrasound therapy and radiof- reguency ablation （RFA） therapy in women with cervicitis related diseases. Methods A total of 200 women with cervicitis related diseases were randomly divided into ultrasound group and RFA group. Postoperative efficacy, side effects and cost of clinical intervention for vaginal bleeding in two groups were observed. Results The total effective rate of cervieitis was 98.89% （89/90） in ultrasound group and 98. 90% （90./91） in RFA group （xz~o. 001, P~0. 99）. The rate of vaginal bleeding needed clinical intervention was lower in ultrasound group （9/95, 9.47 %） than in RFA group （21/96, 21.88%, X2=5.55, P= 0.02）, and acute infection patients in ultrasound group （3/9, 33.33~） were less than in RFA group （16/21, 76.19~, P=0. 04）. Operation fees and examination fees had no significant difference between the two groups （Z=-0.02, --0.61,P〉0.05）. Drug fees and total fees in ultrasound group were significant lower than those in RFA group（Z=-4.39, --3.87, all P〈0.05）. Conclusion Focused ultrasound therapy has the same efficiency for cervicitis related diseases compared with radiofreguency ablation, but has higher security and economic advantages.