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Orbital immunoglobulin‐G4‐related disease: case series and literature review |
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| Authors: | Kaustubh Mulay DNB Ekta Aggarwal MS Mehul Jariwala DNB Santosh G Honavar MS FACS |
| Affiliation: | 1. National Reporting Centre for Ophthalmic Pathology (NRCOP), Centre for Sight, , Hyderabad, India;2. Ophthalmic Pathology Service, L.V. Prasad Eye Institute, , Hyderabad, India;3. Department of Ophthalmic‐Plastics, Vasan Eye Care Hospitals, , Hyderabad, India;4. Department of Pediatric Rheumatology, Sir Ganga Ram Hospital, , New Delhi, India;5. Department of Ocular Oncology and Oculoplastics, Centre for Sight, , Hyderabad, India;6. Department of Ocular Oncology and Oculoplastics, L.V. Prasad Eye Institute, , Hyderabad, India |
| Abstract: | Immunoglobulin‐G4‐related disease (IgG4‐RD) is a distinct group of diseases characterized by elevated serum IgG4 titres and infiltration of affected organs by IgG4‐positive plasma cells. IgG4‐RD can involve any ocular adnexal tissue. They have a distinct prognosis and pattern of tissue involvement and hence need to be differentiated from orbital lesions with similar clinicopathological features. We report three cases of IgG4‐RD and review the literature extensively discussing various aspects of this novel entity. |
| Keywords: | extraocular muscle IgG4‐related disease immunoglobulin‐G4 orbital |