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Stabilization and induction of a lipid peroxidation inhibitor present in the soluble fraction of rat liver homogenates |
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| Authors: | Tetsuya Kamataki Osamu Sugita Naoki Ozawa Haruo Kitagawa |
| Affiliation: | Department of Biochemical Pharmacology, Faculty of Pharmaceutical Sciences, Chiba University, Chiba 280, Japan |
| Abstract: | An inhibitor of lipid peroxidation present in the soluble fraction of rat liver homogenates has been stabilized by dithiothreitol. In the presence of an appropriate concentration of dithiothreitol, soluble fractions from 3-methylcholanthrene-pretreated rats and from older rats exhibited stronger inhibition of lipid peroxidation than those from control rats. |
| Keywords: | Requests for reprints should be sent to Dr. W. L. Nelson Department of Pharmaceutical Sciences University of Washington Seattle Washington 98195. |
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