Palladium(II) Complexes with N‐Heteroaromatic Bidentate Hydrazone Ligands: The Effect of the Chelate Ring Size and Lipophilicity on in vitro Cytotoxic Activity |
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| Authors: | Nenad Filipović Sonja Grubišić Maja Jovanović Marija Dulović Ivanka Marković Olivera Klisurić Aleksandar Marinković Dragana Mitić Katarina Anđelković Tamara Todorović |
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| Affiliation: | 1. Department of Chemistry and Biochemistry, Faculty of Agriculture, University of Belgrade, , 11000 Belgrade, Serbia;2. Center for Chemistry, IHTM, University of Belgrade, , 11000 Belgrade, Serbia;3. Faculty of Medicine, Institute of Medical and Clinical Biochemistry, University of Belgrade, , 11000 Belgrade, Serbia;4. Department of Physics, Faculty of Sciences, University of Novi Sad, , 21000 Novi Sad, Serbia;5. Faculty of Technology and Metallurgy, University of Belgrade, , 11000 Belgrade, Serbia;6. Faculty of Chemistry, University of Belgrade, , 11000 Belgrade, Serbia |
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| Abstract: | Novel Pd(II) complex with N‐heteroaromatic Schiff base ligand, derived from 8‐quinolinecarboxaldehyde (q8a) and ethyl hydrazinoacetate (haOEt), was synthesized and characterized by analytical and spectroscopy methods. The structure of novel complex, as well as structures of its quinoline and pyridine analogues, was optimized by density functional theory calculations, and theoretical data show good agreement with experimental results. A cytotoxic action of the complexes was evaluated on cultures of human promyelocytic leukemia (HL‐60), human glioma (U251), rat glioma (C6), and mouse fibrosarcoma (L929) cell lines. Among investigated compounds, only complexes with quinoline‐based ligands reduce the cell numbers in a dose‐dependent manner in investigated cell lines. The observed cytotoxic effect of two isomeric quinoline‐based complexes is predominantly mediated through the induction of apoptotic cell death in HL‐60 cell line. The cytotoxicity of most efficient novel Pd(II) complex is comparable to the activity of cisplatin, in all cell lines investigated. |
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| Keywords: | apoptosis biological screening chemical structure palladium(II) complexes X‐ray crystallography |
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