Design,Synthesis, and Biological Evaluation of Andrographolide Derivatives as Potent Hepatoprotective Agents |
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| Authors: | Chunlei Tang Guolong Gu Bin Wang Xin Deng Xiaoyun Zhu Hai Qian Wenlong Huang |
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| Affiliation: | 1. State Key Laboratory of Natural Medicines, Centre of Drug Discovery, China Pharmaceutical University, , Nanjing, 210009 China;2. School of Pharmaceutical Science, Jiangnan University, , Wuxi, 214122, China;3. College of Pharmacy, Yancheng Teachers University, , Yancheng, 224002 China;4. R&D Center, Jiangsu Yabang Pharmaceutical Group, , Changzhou, 213163 China;5. Shanghai Institute of Pharmaceutical Industry, , Shanghai, 200040 China |
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| Abstract: | Poor water solubility limits the clinical use of andrographolide and its derivatives. In an attempt to develop potent hepatoprotective drugs, a strategy was proposed to improve the aqueous solubility of andrographolide. Ten andrographolide derivatives were designed, synthesized, evaluated for aqueous solubility and in vivo hepatoprotective activity against CCl4‐induced liver injury in mice. As expected, the aqueous solubility of synthetic derivatives was effectively improved. All compounds demonstrated the effect of different degrees in improving the liver enzyme (ALT and AST) activity, especially the most promising compound 9d significantly improved liver enzyme activity, with high potency to be a new lead. |
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| Keywords: | andrographolide derivatives aqueous solubility hepatoprotective activity synthesis |
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