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Recommendations for HLA‐B*15:02 and HLA‐A*31:01 genetic testing to reduce the risk of carbamazepine‐induced hypersensitivity reactions
Authors:Ursula Amstutz  Neil H. Shear  Michael J. Rieder  Soomi Hwang  Vincent Fung  Hidefumi Nakamura  Mary B. Connolly  Shinya Ito  Bruce C. Carleton  the CPNDS clinical recommendation group
Affiliation:1. Division of Translational Therapeutics, Department of Pediatrics, University of British Columbia, , Vancouver, British Columbia, Canada;2. Pharmaceutical Outcomes Programme, British Columbia Children's Hospital, , Vancouver, British Columbia, Canada;3. Child and Family Research Institute, , Vancouver, British Columbia, Canada;4. Department of Clinical Chemistry, University of Bern and Inselspital University Hospital, , Bern, Switzerland;5. Dermatology, Clinical Pharmacology and Toxicology, Department of Medicine, Sunnybrook Health Sciences Centre, University of Toronto, , Toronto, ON, Canada;6. Clinical Pharmacology, Departments of Medicine, Physiology, Pharmacology and Pediatrics, Schulich School of Medicine and Dentistry, University of Western Ontario, , London, ON, Canada;7. Faculty of Pharmaceutical Sciences, University of British Columbia, , Vancouver, British Columbia, Canada;8. Prohealth Clinical Research Centre, , Vancouver, British Columbia, Canada;9. Departments of Family Medicine and Pathology and Laboratory Medicine, Faculty of Medicine, University of British Columbia, , Vancouver, British Columbia, Canada;10. Division for Clinical Trials, Clinical Research Center, National Center for Child Health and Development, , Tokyo, Japan;11. Division of Neurology, Department of Pediatrics, British Columbia Children's Hospital and University of British Columbia, , Vancouver, British Columbia, Canada;12. Division of Clinical Pharmacology and Toxicology, Department of Pediatrics, The Hospital for Sick Children, University of Toronto, , Toronto, ON, Canada
Abstract:
Keywords:Stevens‐Johnson syndrome  Toxic epidermal necrolysis  Maculopapular exanthema  Drug‐induced hypersensitivity syndrome  Rash  Pharmacogenetic testing
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