| 动脉粥样硬化与脂质氧化损伤及内皮功能关系的研究 |
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| 引用本文： | 张梅,张运,谈红,高月花,张园园.动脉粥样硬化与脂质氧化损伤及内皮功能关系的研究[J].中国医学影像技术,2000,16(10):822-823. |
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| 作者姓名： | 张梅 张运 谈红 高月花 张园园 |
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| 作者单位： | 1. 山东医科大学附属医院，山东济南 250012
2. 济南军区解放军总医院 |
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| 基金项目： | 本课题受卫生部优秀青年科技人才专项基金资助(97037)。 |
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| 摘 要： | 目的 探讨动脉粥样硬化与血管内皮功能、体内脂质氧化和抗氧化功能的关系。方法 测定了血液中氧化修饰低密度脂蛋白（ＯｘＬＤＬ）、丙二醛（ＭＤＡ）、超氧化物岐化酶（ＳＯＤ）、一氧化氮（ＮＯ）和内皮素（ＥＴ）的浓度。结果 与正常组相比较，动脉粥样硬化组ＯｘＬＤＬ、ＭＤＡ、ＥＴ增高，ＮＯ降低（Ｐ〈０．０５），两组ＳＯＤ无显著性差异。结论 超声技术可清楚显示血管壁的早期动脉粥样硬化，动脉粥样硬化斑块形成患者，
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| 关 键 词： | 超声检查 动脉粥样硬化 内皮功能 病理 |
| 文章编号： | 1003-3289(2000)10-0822-02 |
| 收稿时间： | 2000/6/26 0:00:00 |
| 修稿时间： | 2000年6月26日 |
Lipid Oxidation and Endothelial Function in Atherosclerosis |
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| ZHANG Mei,ZHA G Yun,TAN Hong,GAO Yue-tian and ZHANG Yuan-yuan.Lipid Oxidation and Endothelial Function in Atherosclerosis[J].Chinese Journal of Medical Imaging Technology,2000,16(10):822-823. |
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| Authors: | ZHANG Mei ZHA G Yun TAN Hong GAO Yue-tian and ZHANG Yuan-yuan |
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| Institution: | Affiliated Hospital of Shandong Medical University , Jinan 250012 , China;Affiliated Hospital of Shandong Medical University , Jinan 250012 , China;Affiliated Hospital of Shandong Medical University , Jinan 250012 , China;Affiliated Hospital of Shandong Medical University , Jinan 250012 , China |
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| Abstract: | Objective The purpose is to explore the relationship between the atherosclerosis and endothelium function or lipidoxidative function. Methods The association between plasma levels of oxidized LDL,malondiadehyde (MDA),superoxide dismutase (SOD),endothelin (ET),nitric oxide (NO) and AS were investigated. Results The plasma levels of OxLDL, MDA and ET were significantly higher in group A than those of group B( P <0 05),but the level of NO decreased.There was no significant difference in SOD between the two groups ( P >0 05). Conclusion Ultrasound technique provides a reliable approach for detection and monitoring of atherosclerosis. |
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| Keywords: | Ultrasound Atherosclerosis Endothelium function |
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