| 蕨麻提取物抗衰老作用研究 |
| |
| 引用本文： | 谢学渊,王强.蕨麻提取物抗衰老作用研究[J].重庆医学,2007,36(8):734-736. |
| |
| 作者姓名： | 谢学渊 王强 |
| |
| 作者单位： | 海军总医院药剂科,北京,100037;海军总医院药剂科,北京,100037 |
| |
| 摘 要： | 目的 研究蕨麻提取液(JME)对D-半乳糖致衰老小鼠模型的影响,从而探讨JME的抗衰老作用机制.方法 以D-半乳糖致亚急性衰老小鼠为模型,同时给予3种剂量的JME治疗6周后,测定小鼠体内SOD、GSH-Px、Na -K -ATP酶、MAO和MDA等指标,观察JME的延缓衰老作用.结果 与模型组相比,JME能有效改善衰老小鼠的学习记忆能力,提高脑、肝组织的SOD和肝、全血中GSH-Px的活力,提高脑中Na -K -ATP酶水平,显著降低脑中MAO活力,不同程度降低脑、肝、血清中MDA含量.结论 JME可有效延缓模型衰老小鼠衰老体征的出现,具明显抗衰老作用,其作用可能与其清除自由基改善衰老相关酶作用有关.
|
| 关 键 词： | 蕨麻提取物 抗衰老 |
| 文章编号： | 1671-8348(2007)08-734-03 |
| 修稿时间： | 2006-12-12 |
A study on anti-aging action of Potentilla anserina Lextract |
| |
| XIE Xue-yuan,WANG Qiang.A study on anti-aging action of Potentilla anserina Lextract[J].Chongqing Medical Journal,2007,36(8):734-736. |
| |
| Authors: | XIE Xue-yuan WANG Qiang |
| |
| Institution: | Department of Pharmacy, Naval General Hospital, Beijing 100037, China |
| |
| Abstract: | Objective To investigate the effect of Potentilla anserina extract(JME) on aged mice induced by D-galactose.Methods The aged mice were induced by D-galactose.Meanwhile,they were filled with three doses of JME.Then,the ability of memory,the activities of antioxidase in different tissue,the contents of MDA in brain,liver and serum were observed after 6 weeks.Results Compared with the model group,JME could significantly improve the ability of memory,markedly strengthen the activities of SOD in brain and liver,GSH-Px in liver and blood and Na -K -ATPase in brain,decrease the activities of MAO in brain and contents of MDA in brain,liver and serum.Conclusion JME possesses the anti-senility effect probably by improving free radical metabolism. |
| |
| Keywords: | potentilla anserina extract anti-aging |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ |
|
