| 伊维菌素和海群生治疗班氏丝虫病免疫学观察 |
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| 引用本文： | 郑惠君 程式之 等. 伊维菌素和海群生治疗班氏丝虫病免疫学观察[J]. 中国寄生虫学与寄生虫病杂志, 1993, 11(1): 33-37 |
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| 作者姓名： | 郑惠君 程式之 等 |
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| 作者单位： | [1]贵州省寄生虫病研究所，贵阳550001 [2]贵州省药品检验所 |
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| 基金项目： | 世界卫生组织/热带病研究与培训特别规划局/丝虫病专题委员会(WHO/TDR/Fil、ID No.870352)，世界卫生组织/洛克菲勒基金中美协作组(WHO/TDR-RF IDNo.880406)提供资助 |
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| 摘 要： | 应用双盲法以单剂量伊维菌素和标准疗程海群生（DEC）各治疗30例班氏丝虫病，曾经海群生3－4疗程治疗后微丝蚴复现的患者、治疗前和服药后1、2、8、14、30、90、180、和360d检测血清中微丝蚴和成虫的抗原和抗体水平。结果发现：治疗后1－2d，血清HC11，ES34抗原水平呈短暂上升，抗ES抗体水平则明显下降。14d，抗ES、抗成虫抗体均明显升高。90d后ES34、HC11抗原下降、ES34降至接近正常水平。但微丝蚴复现者有回升趋势。伊维菌素组回升更为明显，表明治疗后血清ES34、HC11监测可能有助于考核药物杀灭成虫的疗效。治疗后初期的抗原上升、抗体下降，似反映有免疫复合物形成可能与副作用的出现有关。
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| 关 键 词： | 伊维菌素 海群生 丝虫病 免疫学 |
EFFICACY OF IVERMECTIN FOR CONTROL OF MICROFILAREMIA RECURRING AFTER TREATMENT WITH DIETHYLCARBAMAZINE: IMMUNOLOGICAL OBSERVATION * |
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| Zheng Hui-Jun,Tao Zheng-Hou,Cheng Wen-Fang,Wang Shi-Hai,Cheng Shi-Zhi,Ye Yang-Ming,Luo Lai-Feng,Chen Xiao-Rui,Gan Gen-Bao,and Willy F. Piessens Guizhou Provincial Institute of Parasitic Diseases,Guiyang, China Guizhou Provincial Institute of Pharmacology and Drug Control,Guiyang, China Tongren and Zunyi Prefecture Sanitary and Antiepidemic Stations,Guizhou,, China Harvard School of Public Health,Boston,MA U. S. A. EFFICACY OF IVERMECTIN FOR CONTROL OF MICROFILAREMIA RECURRING AFTER TREATMENT WITH DIETHYLCARBAMAZINE: IMMUNOLOGICAL OBSERVATION *[J]. Chinese Journal of Parasitology and Parasitic Diseases, 1993, 11(1): 33-37 |
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| Authors: | Zheng Hui-Jun Tao Zheng-Hou Cheng Wen-Fang Wang Shi-Hai Cheng Shi-Zhi Ye Yang-Ming Luo Lai-Feng Chen Xiao-Rui Gan Gen-Bao and Willy F. Piessens Guizhou Provincial Institute of Parasitic Diseases Guiyang China Guizhou Provincial Institute of Pharmacology Drug Control Guiyang China Tongren Zunyi Prefecture Sanitary Antiepidemic Stations Guizhou China Harvard School of Public Health Boston MA U. S. A |
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| Affiliation: | Zheng Hui-Jun,Tao Zheng-Hou,Cheng Wen-Fang,Wang Shi-Hai,Cheng Shi-Zhi,Ye Yang-Ming,Luo Lai-Feng,Chen Xiao-Rui,Gan Gen-Bao,and Willy F. Piessens Guizhou Provincial Institute of Parasitic Diseases,Guiyang,550001 China Guizhou Provincial Institute of Pharmacology and Drug Control,Guiyang,550001 China Tongren and Zunyi Prefecture Sanitary and Antiepidemic Stations,Guizhou,554300,563000 China Harvard School of Public Health,Boston,MA 02115 U. S. A |
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| Abstract: | |
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| Keywords: | Ivermectin diethylcarbamazine bancroftian filariasis immunological changes |
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