| 眼针对肠易激综合征大鼠血清和结肠组织中P物质及血管活性肠肽含量的影响 |
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| 引用本文： | 王艳杰,王德山,关洪全,王健,柴纪严,赵金茹,韩晓伟.眼针对肠易激综合征大鼠血清和结肠组织中P物质及血管活性肠肽含量的影响[J].针刺研究,2010,35(1). |
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| 作者姓名： | 王艳杰 王德山 关洪全 王健 柴纪严 赵金茹 韩晓伟 |
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| 作者单位： | 辽宁中医药大学基础医学院,沈阳,110032 |
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| 基金项目： | 国家重点基础研究发展计划(“973”计划)资助项目(No.2007CB512702) |
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| 摘 要： | 目的:观察眼针疗法对肠易激综合征(IBS)大鼠血清和结肠组织中P物质(SP)和血管活性肠肽(VIP)含量的影响,探讨眼针疗法对IBS治疗的作用机制。方法:40只雄性Wistar大鼠随机分为正常组、模型组、眼针组和匹维溴胺组,每组10只。采用慢性应激结合束缚方法建立IBS大鼠模型。眼针组取下焦区、大肠区、肝区、脾区进行针刺,治疗7 d。匹维溴胺组给予匹维溴胺灌胃7 d。HE染色检测结肠组织病理学变化;酶联免疫吸附法测定大鼠血清和结肠组织中SP和VIP含量的变化。结果:各组大鼠结肠组织病理学变化没有明显差异。模型组大鼠与正常组比较,血清和结肠组织中SP和VIP含量显著升高(P0.01);眼针治疗组和匹维溴胺组与模型组比较,血清和结肠组织中SP和VIP含量显著降低(P0.01)。结论:眼针疗法能够降低IBS模型大鼠血清和结肠组织中SP和VIP的含量,从而对IBS起到治疗作用。
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| 关 键 词： | 眼针 肠易激综合征 P物质 血管活性肠肽 |
Effects of Eye-acupuncture Therapy on Serum and Colonic SP and VIP Contents in Rats with Irritable Bowel Syndrome |
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| WANG Yan-jie,WANG De-shan,GUAN Hong-quan,WANG Jian,CHAI Ji-yan,ZHAO Jin-ru,HAN Xiao-wei.Effects of Eye-acupuncture Therapy on Serum and Colonic SP and VIP Contents in Rats with Irritable Bowel Syndrome[J].Acupuncture Research,2010,35(1). |
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| Authors: | WANG Yan-jie WANG De-shan GUAN Hong-quan WANG Jian CHAI Ji-yan ZHAO Jin-ru HAN Xiao-wei |
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| Institution: | WANG Yan-jie,WANG De-shan,GUAN Hong-quan,WANG Jian,CHAI Ji-yan,ZHAO Jin-ru,HAN Xiao-wei(College of Basic Medicine,Liaoning University of Chinese Medicine,Shenyang 110032,China) |
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| Abstract: | Objective To observe the effect of the eye-acupuncture therapy on serum and colonic substance P(SP) and vasoactive intestinal peptide(VIP) contents in rats with irritable bowel syndrome(IBS) so as to explore its underlying mechanism.Methods Forty male Wistar rats were equally randomized into control group,IBS model group,eye-acupuncture group and medication(Pinaverium bromide,7.5mg/kg,twice daily,intragastric administration) group.IBS model was established by giving the rat with chronic stress stimulation(c... |
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| Keywords: | Eye-acupuncture Irritable bowel syndrome SP VIP |
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