正畸力作用下炎性牙周组织的改建

背景:在越来越多的牙周病需要进行正畸治疗时,牙齿移动过程中,炎性牙周组织的改建过程及其机制便成为研究热点.目的:观察在正畸牙移动过程中炎性牙周组织的改建.方法:将50只健康雄性SD大鼠,随机分为正常牙移动组和牙周炎牙移动组,牙周炎牙移动组建立实验性牙周炎动物模型后,所有大鼠建立正畸牙移动模型.分别于牙齿移动后的1,3,5,7和14d,采用苏木精-伊红染色方法观察牙齿受力移动的不同阶段牙周组织的改建.结果与结论:牙周炎牙移动组牙齿移动距离大于正常牙移动组,正畸加力0～7 d,牙周炎牙移动组压力侧破骨现象明显,张力侧成骨活动滞后;加力14 d,牙周炎牙移动组大鼠与正常牙移动组大鼠均以成骨活动为主.伴有牙周炎症的大鼠牙齿移动过程中,牙周及创伤较大,但在去除局部炎性刺激物、牙周炎症得以控制后,可以接受正畸治疗.

Remodeling of inflammatory periodontal tissues during orthodontic tooth movement

BACKGROUND: More and more patients with periodontal disease require orthodontic treatments. Thus, the remodeling process and its mechanism of inflammatory periodontal tissues become a hot point during orthodontic tooth movement.OBJECTIVE: To observe the remodeling of inflammatory periodontal tissues during orthodontic tooth movement.METHODS: A total of 50 Sprague Dawley rats were randomly divided into the control and periodontitis groups. In the periodontitis group, rats were established periodontitis models. After that, all rats were prepared for orthodontic tooth movement models. The remodeling of periodontal tissues was observed by hematoxylin-eosin staining at 1, 3, 5, 7 and 14 days after orthodontic tooth movement.RESULTS AND CONCLUSION: The movement distance of the periodontitis group was greater than that of the control group. At 0-7 days after orthodontic force application, there was obviously bone resorption at the pressure side and the bone formation was inhibited at the tension side; at 14 days after force application, the bone resorption was diminished, associated with large numbers of multinucleated osteoclasts at the pressure sides in both groups. The findings showed that rats with periodontitis suffered more periodontal traumatism during orthodontic tooth movement, thus, treatment should be delayed until the inflammatory signs were controlled and the local inflammatory was eliminated.