| 伊贝母中非生物碱类化学成分的分离与鉴定 |
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| 引用本文： | 李文玲,布仁,陈朝军,俞腾飞,王金辉. 伊贝母中非生物碱类化学成分的分离与鉴定[J]. 中国现代中药, 2013, 15(3): 175-177 |
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| 作者姓名： | 李文玲 布仁 陈朝军 俞腾飞 王金辉 |
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| 作者单位： | 1. 内蒙古医科大学药学院,内蒙古 呼和浩特,010059
2. 内蒙古医科大学药学院,内蒙古 呼和浩特 010059;沈阳药科大学中药学院,辽宁 沈阳 110016 |
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| 摘 要： | 目的：研究伊贝母中非生物碱类化学成分。方法：采用反复硅胶柱色谱、开放ODS柱色谱和HPLC等方法进行分离纯化，并通过NMR技术鉴定其化学结构。结果：从伊贝母乙醇提取物的三氯甲烷萃取部分分离鉴定了7个化合物，分别为（25R）-△5（6）-异螺甾-17α，3β-二醇-3-O-β-D．吡喃葡萄糖基-（1→3）[d-三-吡喃鼠李糖基-（1—2）]-β-D-吡喃葡萄糖苷（1），β-谷甾醇（2），月桂酸（3），反式桂皮酸（4），月桂酸甘油酯（5），胡萝卜苷（6），届-谷甾醇棕榈酸酯（7）。结论：化合物l、7为首次从贝母属中分离得到，4、5为首次从伊贝母植物中分离得到。
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| 关 键 词： | 伊贝母 非生物碱 化学成分 结构鉴定 |
| 收稿时间： | 2012-10-29 |
Isolation and Identification of Non-alkaloid Constituents from Fritillaria pallidiflora Schrenk |
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| Li Wen-ling,Bu Ren,Chen Chao-jun,Yu Teng-fei and Wang Jin-hui. Isolation and Identification of Non-alkaloid Constituents from Fritillaria pallidiflora Schrenk[J]. Modern Chinese Medicine, 2013, 15(3): 175-177 |
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| Authors: | Li Wen-ling Bu Ren Chen Chao-jun Yu Teng-fei Wang Jin-hui |
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| Affiliation: | School of Pharmacy, Inner Mongolia Medical University, Hohhot 010110, China;School of Pharmacy, Inner Mongolia Medical University, Hohhot 010110, China;School of Pharmacy, Inner Mongolia Medical University, Hohhot 010110, China;School of Pharmacy, Inner Mongolia Medical University, Hohhot 010110, China;School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang 110016, China |
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| Abstract: | Objective： To study the non-alkaloid constituents from Fritillaria pallidiflora Schrenk. Methods： Solvent extraction and column chromatography were used to isolate the non-alkaloid constituents, physicochemical properties and spectroscopic analysis were employed for determination of the structures. Results： Seven compounds were isolated, and their structures were identified as （25R） -△5（6）-isospirost-17a, 3/3-diol-3-O-β- D-glucopyranosyl-（ 1 → 3 ） - [ α-L-rhamnopyranosyl-（ 1 → 2 ） ] -β-D- glucopyranoside （ 1 ）, β-sitosterol （ 2 ）, laurostearic acid （ 3）, trans-cinnamic acid （ 4）, lauric acid 1-monoglyceride （ 5 ）, daucosterol （ 6 ）, β-sitosterol palmitate （7） . Conclusion： Compounds 1, 7 were obtained from the Fritillaria genus for the first time and 4, 5 were isolated from this plant for the first time. |
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| Keywords: | Fritillaria pallidiflora Schrenk Non-alkaloids Chemical constituent Structure identification |
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