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肺癌患者肿瘤型M2丙酮酸激酶表达水平及临床意义
引用本文:周向京. 肺癌患者肿瘤型M2丙酮酸激酶表达水平及临床意义[J]. 实用临床医学(江西), 2008, 9(6): 17-19
作者姓名:周向京
作者单位:深圳市第二人民医院检验科 广东深圳518035
摘    要:目的探讨肺癌患者治疗前后血浆中肿瘤型M2丙酮酸激酶(TuM2-PK)的表达水平及其与肿瘤的近期疗效关系。方法用ELISA法分别检测肺癌患者组(n=80)、良性肺部疾病组(n=60)、健康体检组(n=100)血浆中的TuM2-PK的表达水平,并进行比较分析。结果肺癌组TuM2-PK浓度、阳性率(23.1kU/L、69%)明显高于良性肺疾病组(11.5kU/L、5%)和健康对照组(9.1kU/L、3%)(P〈0.01)。经内科治疗后,病情缓解者血浆TuM2-PK浓度(13.1kU/L)与治疗前(21.6kU/L)相比显著下降(P〈0.05);病情进展者血浆TuM2-PK浓度(63.5ku/L)与治疗前(23.4kU/L)相比显著升高(P〈0.05);病情稳定者血浆TuM2-PK浓度治疗前后差异无统计学意义(P〉0.05)。手术后TuM2-PK阳性率显著下降,而化疗后阳性率下降不明显。结论TuM2-PK对肺癌的辅助诊断有较高的临床价值,有助于疗效的评估。

关 键 词:肺肿瘤  肿瘤标志  丙酮酸激酶

The Clinical Value of Tumor Type M2 Pyruvate Kinase Levels in Patients with Lung Cancer
ZHOU Xiang-jing. The Clinical Value of Tumor Type M2 Pyruvate Kinase Levels in Patients with Lung Cancer[J]. Practical Clinical Medicine, 2008, 9(6): 17-19
Authors:ZHOU Xiang-jing
Affiliation:ZHOU Xiang-jing (Department of Laboratory Medicine, Shenzhen Second People's Hospital, Shenzhen 518035, China)
Abstract:Objective To investigate the expression of tumor M2-PK(TuM2-PK)in the patients with lung cancer and their correlation with treatment response.Methods The concentration of TuM2-PK in plasma was detected by ELISA in 100 health controls,60 patients with benign lung disease and 80 with lung cancer.Results TuM2-PK concentration in plasma and positive rate was singificantly higher in lung cancer (23.1kU/L,69%)than that of in benign lung disease and in health controls(11.5kU/L,5%and 9.1kU/L,3%)(P<0.01,respectively).In the patients with tumor remission the TuM2-PK level(13.1 kU/L) was significantly lower than that(21.6 kU/L) in pre-operation (P<0.05).In the patients with progressive disease the TuM2-PK level(63.5 kU/L)was significantly higher than that (23.4 kU/L) of pretreatment(P<0.05).Pre-and post-treatment the TuM2-PK concentration did not differ significantly in patients with stable disease(P>0.05).The positive rates of TuM2-PK decreased significantly after operation,but there was no significant change after chemotherapy.Conclusion The measurement of TuM2-PK is of great clinical value for the diagnosis of lung cancer,and is helpful in the evaluation of treatment response.
Keywords:lung neoplasm  tumor marker  pyruvate kinase
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