Urinary interleukin-6 and interleukin-8 in children with urinary tract infection |
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Authors: | B. A. Jantausch Regina O’Donnell Bernhard L. Wiedermann |
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Affiliation: | (1) Department of Infectious Diseases, Children’s National Medical Center, George Washington University Medical Center, 111 Michigan Ave. NW, Washington, DC 20010, USA e-mail: bjantaus@cnmc.org Tel.: +1-202-8843955, Fax: +1-202-8843850, US;(2) Center for Health Services and Clinical Research, Children’s National Medical Center, George Washington University Medical Center, Washington, DC, USA, US |
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Abstract: | Urinary interleukin-6 (UIL-6) and urinary interleukin-8 (UIL-8) concentrations were measured by immunoassay in 39 and 34 patients respectively, hospitalized with febrile urinary tract infection (UTI), and in 37 and 32 age-, race- and sex-matched febrile control children respectively, with negative urine cultures. UIL-6 and UIL-8 concentrations, measured in picograms per milliliter and corrected for creatinine, were compared with clinical and laboratory indicators of inflammation and bacterial virulence factors of Escherichia coli. Median UIL-6 concentrations at the time of admission were 397 pg/ml (range 0–65,789 pg/ml) in the 37 patients compared to 0 pg/ml (range 0–473.8 pg/ml) in the 37 controls (P<0.0001). Median UIL-8 concentrations at the time of admission were 5809 pg/ml (range 0–347,368 pg/ml) in the 32 patients compared to 0 pg/ml (range 0–2231 pg/ml) in the 32 controls (P<0.0001). UIL-6 and UIL-8 concentrations were lower (P<0.0001 for UIL-6 and P=0.0005 for UIL-8) in follow-up urine samples from UTI patients, obtained 48 h after the initiation of antibiotic therapy. UIL-6 and UIL-8 concentrations were statistically significantly correlated with urine white blood cells (WBC). UIL-8 concentrations were elevated in patients with E. coli organisms producing hemolysin. UIL-6 and UIL-8 are elevated in children with febrile UTI and decrease in response to antibiotic therapy. Magnitude of UIL-8 response is associated with hemolysin production, a bacterial virulence factor of E. coli. UIL-6 and UIL-8 concentrations are statistically correlated with urine WBC. UIL-6 and UIL-8 may be mediators of inflammation in children with febrile UTI. Received: 30 June 1999 / Revised: 29 June 2000 / Accepted: 5 July 2000 |
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Keywords: | Interleukin-6 Interleukin-8 Cytokines Urinary tract infection Escherichia coli |
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