| 基质金属蛋白酶7在肿瘤中的作用研究进展 |
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| 引用本文： | 黄勇,郑树. 基质金属蛋白酶7在肿瘤中的作用研究进展[J]. 上海交通大学学报(医学版), 2010, 30(11): 1428-1432. DOI: 10.3969/j.issn.1674-8115.2010.11.027 |
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| 作者姓名： | 黄勇 郑树 |
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| 作者单位： | 浙江大学,医学院附属第二医院肿瘤研究所,杭州310009 |
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| 摘 要： | 基质金属蛋白酶7（MMP7）通过酶解胞外基质蛋白和抑制fas/fasl介导凋亡信号的转导,在肿瘤发生、发展、预后的预测以及某些药物的耐药方面发挥着重要的作用。文章就MMP7在肿瘤中的作用和可能机制及其在肿瘤治疗方面的研究进展作一综述。
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| 关 键 词： | 基质金属蛋白酶7 fas/fasl 凋亡 肿瘤 |
Research progress of role of matrix metalloproteinase 7 in tumors |
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| HUANG Yong,ZHENG Shu. Research progress of role of matrix metalloproteinase 7 in tumors[J]. Journal of Shanghai Jiaotong University:Medical Science, 2010, 30(11): 1428-1432. DOI: 10.3969/j.issn.1674-8115.2010.11.027 |
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| Authors: | HUANG Yong ZHENG Shu |
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| Affiliation: | Cancer Institute, Second Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou 310009, China |
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| Abstract: | Matrix metalloproteinase 7 (MMP7) plays an important role in tumorigenesis, tumor development and resistance to some anti-tumor medicine by degrading proteins of extracellular matrix and blocking fas/fasl apoptosis signal pathway. This paper discusses the mechanisms by which MMP7 contribute to carcinogenesis, and the research progress of MMP7 in tumor treatment. |
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| Keywords: | matrix metalloproteinase 7 fas/fasl apoptosis neoplasm |
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