甲氨蝶呤与米非司酮联合治疗异位妊娠的临床疗效观察

目的探讨甲氨蝶呤与米非司酮联合治疗异位妊娠的临床疗效。方法128例异位妊娠患者随机分为单用米非司酮组（A组）、单用甲氨蝶呤组（B组）和甲氨蝶呤联合米非司酮组（c组），对3组疗效进行比较。结果A组治愈率76．2％，B组治愈率72．7％，C组治愈率90．4％，C组与A、B组比较，有显著性差异（P〈0．05）。血B—HcG值下降至正常的时间分别为（16．21±2．23）d、（17．14±2．41）d和（12．69±2．12）d，C组与A、B组比较，有显著性差异（P〈0．05）。治疗后C组临床各指标明显缓解（P〈0．05）。结论甲氨蝶呤联合米非司酮是治疗异位妊娠一种安全有效的方法。

Clinical observation of the curative effect of Methotrexate combined with Mifepristone on ectopic pregnancy

Objective To explore the curative effect of methotrexate combined with mifepristone on ectopic pregnancy. Methods 128 cases of ectopic pregnancy were randomly divided into three groups, group A was treated with mifepristone singly, group B was treated with methot rexate,and group C was treated with mifepristone combined with methotrexate. Results The cure ratio of group A, group B and group C was 76.2%, 72.7%, and 90.4% respectively. There was significant difference in group C and group A,B （P〈0.05）.The serum levels of human chorionic gonadotropin （β-HCG）decreased to norml ranges in （16.21 ±2.23） days, （17.14 ±2.41） days and （12.69 ±2.12） days respectively.There was obvious difference between groupC and the others （P〈0.05）.The various clinical indicators of group C had a significant mitigation after treatment （P〈0.05）.Conclusion It was an effective and safe methods for Methotrexate combined with mifepristone in treatment of ectopic pregnancy.