Enhanced clearance of Candida albicans from the oral cavities of mice following oral administration of Lactobacillus acidophilus |
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Authors: | Elahi S Pang G Ashman R Clancy R |
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Affiliation: | Vaccine and Infectious Disease Organization, University of Sasketchewan, Sasketoon, Canada. |
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Abstract: | Orally administered live Lactobacillus acidophilus was assessed for its capacity to enhance clearance from the oral cavity of DBA/2 mice shown previously to be 'infection prone'. L. acidophilus fed to DBA/2 mice significantly shortened the duration of colonization of the oral cavity compared to controls. Enhanced clearance of Candida albicans correlated with both early mRNA gene expression for interleukin (IL)-4 and interferon (IFN)-gamma and expression of their secreted products in cultures of cervical lymph nodes stimulated with Candida antigen. In addition rapid clearance correlated with higher levels of IFN-gamma and nitric oxide in saliva. Delayed clearance, less pronounced levels of the cytokine response, saliva IFN-gamma and nitric oxide, and later mRNA expression for IL-4 and IFN-gamma relative to feeding with the L. acidophilus isolate were noted in mice fed a different Lactobacillus isolate (L. fermentum). These observations indicate significant variations in individual isolates to activate the common mucosal system. |
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Keywords: | C. albicans cytokine lactobacilli nitric oxide |
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