| 肺癌病因研究中接尘量计算的真实性评价 |
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| 引用本文： | 陈卫红,杨剑.肺癌病因研究中接尘量计算的真实性评价[J].工业卫生与职业病,1999,25(3):134-137. |
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| 作者姓名： | 陈卫红 杨剑 |
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| 作者单位： | [1]同济医科大学劳动卫生学教研室 [2]广西大厂矿务局卫生防疫站 |
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| 摘 要： | 为评价肺癌病例对照研究中接尘剂量估算方法的真实性，对广西锡矿病因研究对象进行了重新计算。广西锡矿队列发现男性肺癌死者１３０例，配对照６２７例。共７５７人。其中接法工人５７２名，发现各期矽肺共２４３例，根据在斩工业卫生监测资料估算所有接尘工人的累积总粉尘接触量，再计算不同接尘水平下矽肺的发病率。结果显示，随接尘水平上升，矽肺发病率升高，两者存在明显的接触剂量反应关系。完全符合矽肺发病特点。从而间接证
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| 关 键 词： | 接尘评价 接触剂量 反应关系 矽肺 肺癌 |
Verification of Exposure Assessment Used in a Nested\= Case\|Control Study of Lung Cancer |
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| Chen Weihong et al\=.Verification of Exposure Assessment Used in a Nested\= Case\|Control Study of Lung Cancer[J].Industrial Health and Occupational Diseases,1999,25(3):134-137. |
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| Authors: | Chen Weihong \= |
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| Abstract: | An
indirect verification of a retrospective quantitative assessment of dust exposure used in a
nested case\|control study of lung cancer among Guangxi tin miners was conducted.Cumulative
total dust was calculated for each study subject based on historical industrial hygiene
records.In this cohort,there were 130 male lung cancer cases and 627 controls.Among them
there were 572 exposed miners and 243 of them were diagnosed as silicosis.A significant trend
for exposure dose\|response relationship between the incidence of silicosis and cumulative
total dust exposure was observed in silica exposed workers.The association between the dust
exposure and incidence of silicosis suggested that calculation of cumulative total dust used in
the case\|control study of lung cancer could accurately reflect the exposure dose\|response
relation between silica or dust and lung cancer,if it existed. |
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| Keywords: | Exposure assessment\ Exposure dose\|response\ Silicosis\ Lung cancer |
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