Chitosan-Alginate Scaffold Culture System for Hepatocellular Carcinoma Increases Malignancy and Drug Resistance期刊界 All Journals 搜尽天下杂志传播学术成果专业期刊搜索期刊信息化学术搜索

Chitosan-Alginate Scaffold Culture System for Hepatocellular Carcinoma Increases Malignancy and Drug Resistance

Authors:	Matthew Leung Forrest M. Kievit Stephen J. Florczyk Omid Veiseh Jennifer Wu James O. Park Miqin Zhang

Affiliation:	(1) Department of Materials Science & Engineering, University of Washington, Seattle, Washington 98195, USA;(2) Department of Surgery, School of Medicine, University of Washington, Seattle, Washington 98195, USA;(3) Department of Medicine, School of Medicine, University of Washington, Seattle, Washington 98195, USA;

Abstract:	Purpose Hepatocellular carcinoma (HCC) is a prevalent solid malignancy. Critically needed discovery of new therapeutics has been hindered by lack of an in vitro cell culture system that can effectively represent the in vivo tumor microenvironment. To address this need, a 3D in vitro HCC model was developed using a biocompatible, chitosan-alginate (CA) scaffold cultured with human HCC cell lines.

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