Temporal Expression of Cytokines in Rat Cutaneous,Fascial, and Intestinal Wounds: A Comparative Study |
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| Authors: | Ahmad Zubaidi W Donald Buie David A Hart David Sigalet |
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| Institution: | (1) Department of Surgery, Division of Colorectal Surgery, University of Calgary, Calgary, AB, Canada;(2) Microbiology and Infectious Disease, Department of Medicine and Surgery, University of Calgary, Calgary, AB, Canada;(3) Department of Surgery, Division of Pediatric General Surgery, University of Calgary, Calgary, AB, Canada;(4) Alberta Children’s Hospital, 2888 Shaganappi Trail NW, Calgary, AB, T3B 6A8, Canada; |
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| Abstract: | Background Previous studies have shown that healing in intestinal wounds is proportionally faster than skin. Cytokines and growth factors
play a major role in these coordinated wound-healing events. We hypothesized that this more rapid intestinal healing is due
to an early upregulation of proinflammatory cytokines (IL-1β, TNF-α, and IFN-γ), followed by increases in the expression of
the anti-inflammatory cytokine IL-10 and growth factor TGF-β. |
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