| β-蜕皮甾酮化学结构修饰研究进展 |
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| 引用本文： | 任 健,马丹丹,尚 海,程卯生. β-蜕皮甾酮化学结构修饰研究进展[J]. 中国药物化学杂志, 2009, 19(3): 221-227 |
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| 作者姓名： | 任 健 马丹丹 尚 海 程卯生 |
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| 作者单位： | 沈阳药科大学 制药工程学院， 辽宁 沈阳 110016 |
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| 摘 要： | β-蜕皮甾酮是一种重要的植物甾酮，它参与控制昆虫等无脊椎动物的蜕皮和繁殖过程。药理实验表明β-蜕皮甾酮具有促进蛋白质合成、降低血糖血脂以及改善学习和记忆等多种功效。多年来人们对其化学结构修饰及蜕皮活性的研究取得了一定的进展和成果，该文对历年来β-蜕皮甾酮的化学结构修饰和蜕皮活性研究成果进行概述。
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| 关 键 词： | β-蜕皮甾酮；化学结构修饰；蜕皮活性 |
| 收稿时间： | 2008-12-16 |
| 修稿时间： | 2009-03-18 |
Progress on chemical structural modification of 20-hydroxyecdysone |
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| REN Jian,MA Dan-dan,SHANG Hai,Cheng Mao-sheng. Progress on chemical structural modification of 20-hydroxyecdysone[J]. Chinese Journal of Medicinal Chemistry, 2009, 19(3): 221-227 |
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| Authors: | REN Jian MA Dan-dan SHANG Hai Cheng Mao-sheng |
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| Affiliation: | School of Pharmaceutical Engineering, Shenyang Pharmaceutical University, Shenyang 110016, China |
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| Abstract: | 20-Hydroxyecdysone is an important ecdysteroid. The physiological functions in invertebrates including insects are to control moulting and reproduction. Pharmacological research indicated that 20-hydroxyecdysone could promote the protein synthesis, decrease the blood glucose and lipid, and improve the ability of learning and memory. Research progress on 20-hydroxyecdysone chemical structural modification and their biological activity are reviewed. Key words: 20-hydroxyecdysone; chemical structural modification; moulting hormone activity |
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| Keywords: | 20-hydroxyecdysone chemical structural modification moulting hormone activity |
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