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Linkage of a commoner form of recessive amyotrophic lateral sclerosis to chromosome 15q15-q22 markers |
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| Authors: | Afif Hentati Karim Ouahchi Margaret A. Pericak-Vance Deepak Nijhawan Arsalan Ahmad Y. Yang Jackie Rimmler W.-Y. Hung Beate Schlotter Akhtar Ahmed Mongi Ben Hamida Fayçal Hentati T. Siddique |
| Affiliation: | (1) Northwestern University Medical School, Tarry Building Room 13-715, 300 E. Superior Street, Chicago, Illinois 60611, USA Tel: (312) 503 4737; Fax: (312) 908 0865 e-mail: A. Hentati: afif@nwu.edu, T. Siddique: t-siddique@nwu.edu, US;(2) Duke University Medical Center, Durham, North Carolina, USA, US;(3) Dow Medical College, Civil Hospital, Karachi, Pakistan, PK;(4) Friedrich-Baur Institut, Klinikum Innenstadt-Ludwig Maximilians Universitat, Munich, Germany, DE;(5) Institut National de Neurology, La Rabta 1007, Tunis, Tunisia, |
| Abstract: | Autosomal recessive familial amyotrophic lateral sclerosis (RFALS) is a rare form of ALS that usually presents at an early age with slow progression of symptoms. RFALS is clinically and genetically heterogeneous and the locus of RFALS type 3 was mapped to 2q33 (ALS2) in a single family. We now report linkage of a more-common form of RFALS to chromosome 15q15-q22 markers (ALS5) and show further genetic locus heterogeneity in RFALS. ALS5 is the locus for most families with RFALS and appears to be present in both North African and European populations. Received: July 22, 1998 / Accepted: September 18, 1998 / Published online: December 18, 1998 |
| Keywords: | Recessive amyotrophic lateral sclerosis Chromosome 15q15-q22 markers |
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