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| 大黄廑虫丸治疗肾纤维化血瘀证的临床研究 | |
| 引用本文： | 金亚明,殷敏,邓跃毅,何立群,朱戎,张志刚,张春菘,钟逸斐,张金福. 大黄廑虫丸治疗肾纤维化血瘀证的临床研究[J]. 中国中西医结合肾病杂志, 2009, 10(9): 788-790 |
| 作者姓名： | 金亚明 殷敏 邓跃毅 何立群 朱戎 张志刚 张春菘 钟逸斐 张金福 |
| 作者单位： | 1. 上海中医药大学附属龙华医院,上海,200032 2. 上海中医药大学附属曙光医院,上海,200020 3. 复旦大学医学院病理教研室,上海,200032 |
| 基金项目： | 上海市卫生局基金资助项目(No.03-4067) |
| 摘 要： | 目的：观察大黄座虫丸对肾纤维化血瘀证的，临床疗效，扩大其临床适应证。方法：108例各类慢性肾小球肾炎患者，均经肾穿刺确诊，肾组织纤维化病理积分≥5分，以前瞻、随机、单盲、对照法分为治疗组72例，对照组36例，两组均予贝那普利和潘生丁口服，治疗组另予大黄座虫丸口服，疗程为4个月。结果：两组治疗后Scr、24h尿蛋白定量、血清纤维连接蛋白（FN）、层黏连蛋白（LN）、血栓烷B2（TXB2）、纤溶酶原活化抑制剂（PAI）等水平的改变均较治疗前有明显好转（P〈0．05），治疗组的血瘀证积分较治疗前及对照组差异都有统计学意义（P〈0．01），治疗组BUN及TXB2的下降更为显著（P〈0．05），治疗组的重复肾穿病例，其病理改变显著优于对照组的病例。结论：以上述方法控制肾纤维化进展的临床疗效确切，所检测指标和病理改变差异都有统计学意义．来发现明显毒副作用。 |
| 关 键 词： | 大黄座虫丸 肾纤维化 血瘀证 肾穿刺 |
Clinical Study of Treating Blood Stasis of Kidney Fibrosis with Dahuang Zhechong Wan |
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| JIN Yaming,YIN Min,DENG Yueyi,et alNephropathy Dept,Longhua Hospital,Shanghai University of Traditional Chinese Medicine,Shanghai. Clinical Study of Treating Blood Stasis of Kidney Fibrosis with Dahuang Zhechong Wan[J]. Chinese Journal of Integrated Traditional and Western Nephrology, 2009, 10(9): 788-790 | |
| Authors: | JIN Yaming YIN Min DENG Yueyi et alNephropathy Dept Longhua Hospital Shanghai University of Traditional Chinese Medicine Shanghai |
| Abstract: | Objective:To investigate the effect of"Dahuang Zhechong Wan"on blood stasis of kidney fibrosis,to extend its clinical usage.Methods:108subjects diagnosed by renal biopsy were divided into treatment group(72 subjects)and control group(36 subjects).Treatment group was treated by"Dahuang Zhechong Wan",benazepril,persantin and control group was treated by benazepril and persantin for 4 months.Results:After treatment,in two groups those presenting a significant difference statistically are Scr,FN,LN,TXB2,and PAI... |
| Keywords: | Dahuang zhechong wan Kidney fibrosis Blood stasis Renal biopsy |
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