Nitric oxide and cyclic GMP levels in sickle cell patients receiving hydroxyurea |
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| Authors: | Nahavandi Masoud Tavakkoli Fatemeh Wyche Melville Q Perlin Elliott Winter William P Castro Oswaldo |
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| Institution: | Department of Anaesthesiology, and Center For Sickle Cell Disease, College of Medicine, Howard University, Washington, DC 20060, USA. mnahavandi@Howard.edu |
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| Abstract: | Recent studies suggest that nitric oxide (NO) may partly be responsible for the beneficial effect of hydroxyurea (HU) in sickle cell disease (SCD) patients. NO stimulates cyclic guanosine monophosphate (cGMP) production, which mediates vasodilatation. We investigated the association between NO, cGMP and fetal haemoglobin (HbF) levels after HU administration. Our data showed that chronic HU significantly increased NO, cGMP, and HbF levels in SCD. Recently it was shown that HbF production was stimulated by cGMP-dependent protein kinase. Our results suggest that NO stimulates cGMP production, which then activates a protein kinase and increases the production of HbF. |
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| Keywords: | hydroxyurea nitric oxide metabolites sickle cell disease vaso-occlusive crisis cyclic guanosine monophosphate fetal haemoglobin |
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