| 89SrCl2治疗无骨痛的多发性骨转移瘤的效果 |
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| 引用本文： | 欧阳伟,刘金华,刘伟英. 89SrCl2治疗无骨痛的多发性骨转移瘤的效果[J]. 南方医科大学学报, 2007, 27(3): 390-391 |
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| 作者姓名： | 欧阳伟 刘金华 刘伟英 |
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| 作者单位： | 南方医科大学珠江医院核医学科,广东,广州,510282;南方医科大学珠江医院核医学科,广东,广州,510282;南方医科大学珠江医院核医学科,广东,广州,510282 |
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| 摘 要： | 目的 评价89SrCl2治疗无骨痛的多发性骨转移瘤的疗效和安全性.方法 54例不伴骨痛的多发性骨转移瘤病人,首次静脉注射89SrCl2,剂量根据体质量计算为1.48～2.22MBq/kg,重复给药间隔3～6个月,给药次数为1～3次.结果 54例病人中,总有效率为74.0%,病灶直径＞2 cm病人的有效率较≤2 cm病人明显为低(33.3% vs 66.6%,χ2=14.9,P＜00.1).89SrCl2治疗的副作用为白细胞和血小板降低,但绝大数病人为轻度降低,且可以恢复正常,无需特别处理.结论 89SrCl2治疗无骨痛的多发性骨转移瘤有效且安全.
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| 关 键 词： | 骨肿瘤 肿瘤转移 锶/放射性同位素 放射疗法 |
| 文章编号： | 1673-4254（2007）03-0390-02 |
| 收稿时间： | 2006-03-18 |
| 修稿时间： | 2006-03-18 |
Therapeutic efficacy of strontium-89-chloride for bone metastatic tumors without bone pain |
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| OUYANG Wei,LIU Jin-hua,LIU Wei-ying. Therapeutic efficacy of strontium-89-chloride for bone metastatic tumors without bone pain[J]. Journal of Southern Medical University, 2007, 27(3): 390-391 |
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| Authors: | OUYANG Wei LIU Jin-hua LIU Wei-ying |
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| Affiliation: | Department of Nuclear Medicine, Zhujiang Hospital, South Medical University, Guangzhou 510282, China. oyw88@ tom.com |
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| Abstract: | OBJECTIVE: To evaluate the safety and efficacy of strontium-89-chloride for management of bone metastases in patients without bone pain. METHODS: Fifty-four patients without painful bone metastases were given a single intravenous dose (1.48-2.22 MBq/kg) of strontium-89-chloride, which was repeated once or twice at the interval between 3 and 6 months. RESULTS: The total response rate was 74.0% in these, and the response rate was significantly lower in patients with focal size>2 cm than in those with focal size
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| Keywords: | bone neoplasms neoplasm metastasis strontium/radioisotopes radiotherapy |
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