善得定、垂体后叶素对肝硬化食管胃底静脉破裂出血研究

目的：研究善得定（生长抑素八肽）与国产垂体后叶素在肝硬化食管胃底静脉曲线破裂出血中的止血效果，同时观察了再出血率，病死率和副反应。方法：对102例病例根据经济情况，有无心血管病史随机分为两组，治疗组 静推0.1mg善得定后给36ug/h速度持续静点，垂体后叶素组给垂体后叶素0.4u/min持续静点。结果：善得定治疗组3小时、6小时、12小时、24小时完全止血率依次为16.67%、25%、61.15%和80.56%，垂体后叶素组依次为10％、20％、40％、50％。结论：持续静脉点滴善得定在相同时限止血疗效均较垂体后叶素效果明显，而且副作用少，再出血和存活率两组产现例无明显差异。

Clinical study on SaMdostatin and Pituitrine in treatnent of esophageal gastric varices bleedig in patients with live cirrhosis

OBJECTIVE:To study whether sandostatin and domestic pituitrine is more effective for stopping bleed in the treatment of recurrent esophageal gastric varices bleeding(EGVB) in patients with liver cirrhosis, and observe the rebleeding rate, mortality rate and side effects. METHODS:According to their economy situation and cardiovascular disease history, 102 patients were randomly divided into two groups, After the injection of 0 1mg sandostatin, the trentment group continued to receive it by ivdrip instantly at the flow rate of 36ugh -1 , the other group kept intraveaous dripping of pituitrine 0 4 u min -1 .RESULTS:At the time of 3h, 6h, 12h, and 24h, the complete stopbleeding rate of the sandostatin group was 16 67%, 25%, 61 35% and 80 56% respectively, at the same time, the rate of the other group was 10%, 20%, 40%, and 50% respectively. CONCLUSION:During the same time, the stop bleeding result of sandostatin iv drip continuously is far better than the one of pituitrin's, besides with less side effect, however, there is no obvious difference between the two groups in rebleeding rate and survival rate.