他克莫司软膏联合窄谱中波紫外线治疗面颈部白癜风疗效观察

目的:评价外用0.1%他克莫司软膏联合窄谱中波紫外线(NB-UVB)治疗面、颈部白癜风的临床疗效和不良反应.方法:将82例面颈部自癜风患者随机分成3组.A组:外用0.1%他克莫司软膏联合NB-UVB照射.B组:单独给予NB-UVB照射.C组:单独外用0.1%他克莫司软膏.疗程均为16周.试验结束时依据治疗前、后患者皮损的照片进行疗效评价.结果:治疗结束后,A、B、C3组有效率分别为78.6%(22/28),48.1%(13/27),51.9%(14/27);A组有效率与B、C两组相比.差异有统计学意义(P值均<0.05).A组与C组的复色开始平均时间相比,差异无统计学意义(P>0.05),但二者分别与B组相比,差异均有统计学意义(P值均<0.05).A组、c组中患者不同分期皮损的有效率差异有统计学意义(P<0.05),B组差异则无统计学意义(P>0.05).3组患者中不同部位皮损的疗效比较差异均无统计学意义(P值均>0.05).3组患者治疗部位出现灼热感、瘙痒的概率很低,且症状轻微.结论:他克莫司软膏治疗面、颈部白癜风起效快、疗效好、不良反应少,联合NB-UVB照射能进一步提高疗效.

Combination of topical tacrolimus ointment and NB-UVB for vitiligo on the face and neck

Objective:To evaluate the efficacy and safety of topical tacrelimus 0.1%creanl and NB-UVB for the treatment of vitiligo on the face and neck. Methods:A randomized experimental controlled study was performed in 82 patients,they were randomly divided into three groups:group A,receiving topical tacrolimus 0.1%creanl as well as NB-UVB thempy;group B,singly receiving NB-UVB thempy;group C,sinOy receiving topical tacrolimus 0.1%.All patients were treated for 16 weeks.Efficacy was analyzed using digital photography taken before and after treatment. Results:After therapy,the re-sponse rates were 78.6%, 48.1%and 51.9%respectively in group A, B and C.The response rate waft,higher in group A than in group B and C(both P<0.05).The average time of color restoration was longer in group B than that of group A and C(both P<0.05),but there Wus no difference between group A and C.The response rates of different period were different in group A(P<0.05),and also in group C(P<0.05),but not in group B(P>0.05).The response rate of lesions on the face had no difference with lesions on the neck among all patients.Patients hardly appeared burning sensation and itching. Conclusions:Topical tacmlimus ointment is safe, effective and well-tolerated for vitiligo on the face and neck,The combination age of topical tacrolimus and NB-UVB may impmve its efficacy.