| 慢性染铅大鼠血清SOD、MDA的时间效应研究 |
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| 引用本文： | 张国辉,王世鑫,周蔚,王俊虹,魏茂提,韩景田.慢性染铅大鼠血清SOD、MDA的时间效应研究[J].武警医学院学报,2001,10(3):189-191. |
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| 作者姓名： | 张国辉 王世鑫 周蔚 王俊虹 魏茂提 韩景田 |
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| 作者单位： | 武警医学院军事医学教研室,天津,300162 |
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| 基金项目： | 武警医学院科研基金资助(WY98-05) |
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| 摘 要： | 目的研究慢性染铅大鼠血铅与血清SOD、MDA的时间变化效应,探讨SOD、MDA在铅中毒中的变化.方法SOD活性测定采用亚硝酸盐显色法,MDA含量测定采用硫代巴比妥(TBA)法.结果低剂量染铅大鼠血清SOD活力在60天以后低于对照组(P＜0.05),高剂量染铅组SOD活力30天以后明显低于对照组(P＜0.05).高剂量染铅组MDA含量30天以后明显高于对照组(P＜0.05).结论慢性染铅过程中,SOD活性随染铅时间延长逐渐降低,MDA含量随染铅时间延长逐渐增加.
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| 关 键 词： | 铅染毒 超氧化物歧化酶 丙二醛 SOD MDA 血清学检验 |
| 文章编号： | 1008-5041(2001)03-0189-03 |
| 修稿时间： | 2000年10月8日 |
Time series changes of SOD、 MDA in serum result from chronic lead exposure |
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| ZHANG Guo-hui,WANG Shi-xin,ZHOU Wei,et al..Time series changes of SOD、 MDA in serum result from chronic lead exposure[J].Acta Academiae Medicinae CPAPF,2001,10(3):189-191. |
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| Authors: | ZHANG Guo-hui WANG Shi-xin ZHOU Wei |
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| Institution: | ZHANG Guo-hui,WANG Shi-xin,ZHOU Wei,et al.Department of military mediline,Medical College of Chinese People's Armed Police Force,Tianjin 300162 |
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| Abstract: | Objective:To investigate the changes of super oxide dismutase (SOD) activity and malondialdehyde (MDA) content in serum of rats exposed to excess lead following the time.Methods:SOD activity in serum was measured by nitrat coloration and MDA content by TBA method. Results:Compared with control group, the activity of SOD in blood was markedly lower in low-dose group after 60 days , and 30 days in high-dose group (P <0 05). MDA level in blood of control group was significantly lower than the high-dose group after 30 days. Conclusion:During chronic lead poisoning , lead can lead to the decrease of SOD activity and the increase of MDA content as time goes by. |
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| Keywords: | Lead poisoning SOD MDA |
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