既往肝外恶性肿瘤病史患者的肝脏移植

 目的 探讨既往有肝外恶性肿瘤病史患者的肝移植手术适应症和疗效。方法 2例术前分别因直肠癌和乳腺癌接受过根治性外科手术的患者,因肝癌或肝硬化接受同种异体原位肝移植术,术后采用个体化免疫抑制治疗方案,并对肝癌患者行术后常规化疗。 结果 2例患者术后恢复顺利,分别随访79个月年及34个月,肝功能良好,既往肝外肿瘤均未见复发。 结论 对既往有肝外恶性肿瘤的患者,肝移植手术并非禁忌,挑选合适的受者并采取个体化免疫抑制和化疗方案,可以取得满意疗效。

Liver transplantation in patients with previous extrahepatic malignancies

Objective To identify the indication of liver transplantation for patients with previous extrahepatic malignancies.Methods Two patients with hepatocellular carcinoma or liver cirrhosis,had suffered with rectal cancer or breast cancer,both of them had received radical surgery before receiving orthotopic liver transplantation and postoperative treatment of individualized immunosuppressive therapy.Results The patients recovered well after surgery,followed up for 79 months and 34 months with normal liver function,no tumor recurrence.ConclusionsPrevious extrahepatic malignancy should not be considered as a contraindication for liver transplantation,selection of suitable patient and to take individual immunosuppressive and chemotherapy,can achieve satisfactory results.