蜕膜间充质干细胞免疫调节作用及临床应用研究进展

蜕膜间充质干细胞除了具有间充质干细胞一般表型及分化潜能外,还具有低免疫原性等独特性质,是一种多能基质细胞。蜕膜间充质干细胞不但为妊娠期间胚胎植入提供适宜环境,而且通过表达免疫调控因子与多种免疫细胞相互作用,如T细胞、NK细胞及DC等,发挥其在胚胎植入、免疫耐受建立及正常妊娠维持中的重要作用。目前蜕膜间充质干细胞已经应用于造血干细胞移植、再生治疗等,具有较高的临床应用价值。本文就蜕膜间充质干细胞的来源、特征、功能及临床应用前景等进行综述。

The progress of studies on immunomodulation and clinical application of decidual mesenchymal stem cells

Decidual mesenchymal stem cells(DMSCs),a subtype of the multipotient stromal cells,are characterized by stemness phenotype,low immunogenicity and differentiation potential similar with other MSCs.DMSCs not only provide suitable microenvironment for embryo implantation during gestation,but also secret the immnomodification cytokines,or interaction with many immunocytes,such as T cells,NK cells,DCs.DMSCs play an important role in embryo implantation,immunotolerance establishment as well as pregnancy maintainance,thus may be an attractive source for clinical application.DMSCs has currently been applied on hematopoietic stem cell transplantation,or regeneration therapy et al.The source,characteristics,function and potential uses in future therapy are reviewed in this paper.