| CXCL12-CXCR4/CXCR7轴信号传导通路与肿瘤细胞生物学特性的关系 |
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| 引用本文： | 喻松霞,李剑.CXCL12-CXCR4/CXCR7轴信号传导通路与肿瘤细胞生物学特性的关系[J].基础医学与临床,2012,32(3):349-353. |
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| 作者姓名： | 喻松霞 李剑 |
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| 作者单位： | 喻松霞 (南昌大学第二附属医院血液科,江西南昌330006) ； 李剑 (南昌大学研究生院医学部,江西南昌330006) ； |
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| 摘 要： | 越来越多的研究表明CXCR4与CXCR7在肿瘤的发生发展过程中发挥着重要作用,CXCR4与CXCR7作为G蛋白藕联受体介导的信号传导通路及其在胞内激化级联信号通路与肿瘤发生发展的分子机制有密切关系。本文将对它们各自介导的信号通路及其在胞内的级联信号通路与肿瘤细胞的生长、增殖、黏附和迁移等生物学特性的关系进行综述。
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| 关 键 词： | CXCR4 CXCR7 信号传导 肿瘤 |
The relationship between CXCL12-CXCR4/CXCR7 axis signal transduction and the biological features of tumor |
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| YU Song-xia,LI Jian.The relationship between CXCL12-CXCR4/CXCR7 axis signal transduction and the biological features of tumor[J].Basic Medical Sciences and Clinics,2012,32(3):349-353. |
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| Authors: | YU Song-xia LI Jian |
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| Institution: | 1(1.Dept.of Hematology,Second Affiliated Hospital,Nanchang University;2.Dept.of Medicine,Graduate School,Nanchang University, Nanchang 330006,China) |
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| Abstract: | More and more research results have demonstrated that CXCR4 and CXCR7 as G-protein coupled receptors(GPCRs) are important mediators and cascaders of cellular signal transduction,which is closely revelent to tumorigenesis.In this paper we review the relationship between their respective signaling modules,the cascade of intracellular signal pathways and biological features of tumor,such as growth,proliferation,adhesion,migration and so on. |
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| Keywords: | CXCR4 CXCR7 signal transduction tumor |
| 本文献已被 CNKI 等数据库收录！ |
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