Whole-body iodine-131 metaiodobenzylguanidine imaging for detection of bone metastases in patients with paraganglioma: comparison with bone scintigraphy |
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| Authors: | Tetsuya Inoue Keiichiro Yoshinaga Koichi Morita Tohru Shiga Kakuko Kanegae Kenji Hirata Shozo Okamoto Nagara Tamaki |
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| Affiliation: | (1) Department of Nuclear Medicine, Hokkaido University Graduate School of Medicine, Kita 15 Nishi 7, Kita-Ku, Sapporo 060-8638, Japan;(2) Department of Molecular Imaging, Hokkaido University Graduate School of Medicine, Sapporo, Japan |
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| Abstract: | Iodine-131 metaiodobenzylguanidine (131I-MIBG) therapy is an effective treatment for patients with malignant paraganglioma for which surgical resection is not indicated. We performed high-dose 131I-MIBG therapy on two patients with malignant paraganglioma and multiple bone metastases. The bone metastases were diagnosed by magnetic resonance imaging (MRI). Metastatic bone lesions were evaluated by whole-body 131I-MIBG imaging and bone scintigraphy. Whole-body 131I-MIBG imaging showed extensive metastatic bone lesions, whereas conventional bone scintigraphy did not. There was a remarkable discrepancy between 131I-MIBG imaging and bone scintigraphy in the diagnosis of metastatic bone lesions of malignant paraganglioma in our two patients. High-dose 131I-MIBG imaging may detect early stages of bone metastases, compared with bone scintigraphy, in patients with malignant paraganglioma. |
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| Keywords: | Paraganglioma Bone metastases 131I-MIBG therapy Bone scintigraphy |
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