Experience with the Wujciak-Opelz allocation system in a single center: an increase in HLA-DR mismatching and in early occurring acute rejection episodes |
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Authors: | P Vereerstraeten Daniel Abramowicz Luc De Pauw Paul Kinnaert |
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Institution: | (1) Department of Nephrology, Dialysis, and Transplantation, CUB Erasmus Hospital, Route de Lennik 808, B-1070 Brussels, Belgium Fax: + 32 2 555 64 99, BE |
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Abstract: | The present single-center, retrospective study was undertaken to assess the impact of the Wujciak-Opelz allocation system
(XCOMB), currently used within Eurotransplant for renal allografts, on the incidence of early occurring rejection episodes
(RE). Implementation of the system resulted in an increase of HLA-DR mismatches (MM), while the incidence of HLA-A + B + DR
MM remained unchanged. During the 1st post-transplant month, the total number of RE, expressed per patient-months, increased
by 64 % (0.326 vs 0.199, P = 0.007); when considering only severe and irreversible RE, the increase was 76 % (0.158 vs 0.090, P = 0.011). In contrast, from the 2nd to the 12th post-transplant month, the incidence of RE, regardless of severity, was similar
before and after implementation of XCOMB. As early occurring RE have detrimental effects on long-term graft outcome, these
observations, if confirmed on a larger scale, would justify changes in the allocation algorithm.
Received: 13 February 1998 Received after revision: 29 April 1998 Accepted: 20 May 1998 |
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Keywords: | Kidney transplantation HLA-DR mismatches Wujciak-Opelz allocation system Wujciak-Opelz allocation system HLA mismatches kidney transplantation HLA mismatches Wujciak-Opelz allocation system kidney transplantation Acute rejection kidney transplantation Wujciak-Opelz allocation system |
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