丹参对妊娠高血压患者TXA2/PgI2、血液流变学和肾功能的影响 |
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引用本文: | 林虹,罗利飞.丹参对妊娠高血压患者TXA2/PgI2、血液流变学和肾功能的影响[J].中国药师,2009,12(10):1358-1360. |
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作者姓名: | 林虹 罗利飞 |
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作者单位: | 1. 台州市椒江妇幼保健所妇产科,浙江台州,318000 2. 台州医院检验科 |
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摘 要: | 目的:观察丹参对妊娠高血压疾病(PIH)患者血浆血栓素A2(TXA2)/依前列醇(PgI2)平衡、血液流变学和肾功能的影响。方法:选择50例轻中度PIH患者予以丹参8ml,ivd,qd×10d(PIH组),观察治疗前后血浆TXA2和PgI2含量、血液流变学和尿微量蛋白(U-MALB)、β2-微球蛋白(β2-MG)含量的变化。另取正常妊娠对照组30例。结果:与正常妊娠对照组比较,PIH组患者血浆TXA2含量上升,PgI2含量下降;全血高切黏度、全血低切黏度、红细胞聚集指数、红细胞压积和血浆黏度均明显增加;尿U—MALB和β2-MG含量均显著升高。经过丹参治疗10d后,患者血浆TXA2含量下降,PgI2含量上升;血液流变学指标明显改善;尿U-MALB和β2--MG含量明显降低。结论:PIH患者存在血浆TXA2/P凼比值升高、血液处于高凝状态和肾功能的损害。丹参治疗PIH的作用机制可能是通过纠正血浆TXA2/PgI2比值失衡,改善血液流变学和保护肾功能的作用。
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关 键 词: | 妊娠高血压疾病 丹参 血栓素A2 前列环素 血液流变学 肾功能 |
Influence of Danshen on Plasma Thromboxane A2/Epoprosteno Balance, Hemorheology and Renal Function in Patients with Pregnancy-induced Hypertension |
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Institution: | Lin Hong, Luo Lifei(1. Department of Obstetrics & Gynecology, Maternity and Child Care Centers of Jiaojiang District, Zhejiang Taizhou 318000, China;2. Clinical Laboratory, Taizhou Hospital, Taizhou) |
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Abstract: | Objective: To observe the influence of Danshen on plasma thromboxane A2 (TXA2)/prostacyclin( PgI2 ) balance, hemorheology and renal function in patients with pregnancy-induced hypertension (PIH). Method : Fifty cases of patients with mild to moderate PIH were given a 10-day Danshen 8ml ivd( PIH group) , plasma TXA2 and PgI2 levels, hemorrheology, urine U-MALB, β2- MG level changes were observed before and after treatment. Thirty cases of mormal pregnancy were chosen as normal control group. Result: Compared with the control group of normal pregnancy, plasma TXA2 contents were increased, PgI2 contents were decreased ; high shear of whole blood viscosity, low shear of whole blood viscosity, erythrocyte aggregation index, hematocrit and plasma viscosity were significantly increased; urine U-MALB and β2-MG levels were significantly increased in PIH group. After 10 days of Danshen treatment, plasma TXA2 contents were decreased, PgI2 contents were increased; the indicators in hemorheology were significantly improved; urine U-MALB and β2-MG were significantly reduced. Conclusion: Plasma TXA2/PgI2 ratio was increased, blood is in a hyper-coagulablility state and renal function is impaired in PIH patients. The mechanism of PIH treatment with Danshen may be through correcting the imbalance of plasma TXA2/ PgI2 ratio, improving blood hemorheology and protection of renal function. |
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Keywords: | Pregnancy-induced hypertension Danshen Thromboxane A2 Prostacyclin Hemorheology Renal function |
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