丹参对妊娠高血压患者TXA2／PgI2、血液流变学和肾功能的影响

目的：观察丹参对妊娠高血压疾病（PIH）患者血浆血栓素A2（TXA2）／依前列醇（PgI2）平衡、血液流变学和肾功能的影响。方法：选择50例轻中度PIH患者予以丹参8ml，ivd，qd×10d（PIH组），观察治疗前后血浆TXA2和PgI2含量、血液流变学和尿微量蛋白（U-MALB）、β2-微球蛋白（β2-MG）含量的变化。另取正常妊娠对照组30例。结果：与正常妊娠对照组比较，PIH组患者血浆TXA2含量上升，PgI2含量下降；全血高切黏度、全血低切黏度、红细胞聚集指数、红细胞压积和血浆黏度均明显增加；尿U—MALB和β2-MG含量均显著升高。经过丹参治疗10d后，患者血浆TXA2含量下降，PgI2含量上升；血液流变学指标明显改善；尿U-MALB和β2--MG含量明显降低。结论：PIH患者存在血浆TXA2／P凼比值升高、血液处于高凝状态和肾功能的损害。丹参治疗PIH的作用机制可能是通过纠正血浆TXA2／PgI2比值失衡，改善血液流变学和保护肾功能的作用。

Influence of Danshen on Plasma Thromboxane A2/Epoprosteno Balance, Hemorheology and Renal Function in Patients with Pregnancy-induced Hypertension

Objective： To observe the influence of Danshen on plasma thromboxane A2 （TXA2）/prostacyclin（ PgI2 ） balance, hemorheology and renal function in patients with pregnancy-induced hypertension （PIH）. Method ： Fifty cases of patients with mild to moderate PIH were given a 10-day Danshen 8ml ivd（ PIH group） , plasma TXA2 and PgI2 levels, hemorrheology, urine U-MALB, β2- MG level changes were observed before and after treatment. Thirty cases of mormal pregnancy were chosen as normal control group. Result： Compared with the control group of normal pregnancy, plasma TXA2 contents were increased, PgI2 contents were decreased ; high shear of whole blood viscosity, low shear of whole blood viscosity, erythrocyte aggregation index, hematocrit and plasma viscosity were significantly increased; urine U-MALB and β2-MG levels were significantly increased in PIH group. After 10 days of Danshen treatment, plasma TXA2 contents were decreased, PgI2 contents were increased; the indicators in hemorheology were significantly improved; urine U-MALB and β2-MG were significantly reduced. Conclusion： Plasma TXA2/PgI2 ratio was increased, blood is in a hyper-coagulablility state and renal function is impaired in PIH patients. The mechanism of PIH treatment with Danshen may be through correcting the imbalance of plasma TXA2/ PgI2 ratio, improving blood hemorheology and protection of renal function.