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Cholesterol retention in Alzheimer's brain is responsible for high beta- and gamma-secretase activities and Abeta production
Authors:Xiong Huaqi  Callaghan Debbie  Jones Aimee  Walker Douglas G  Lue Lih-Fen  Beach Thomas G  Sue Lucia I  Woulfe John  Xu Huaxi  Stanimirovic Danica B  Zhang Wandong
Affiliation:aNeurobiology Program, Institute for Biological Sciences, National Research Council of Canada, Ottawa, Canada K1A 0R6;bFaculty of Medicine, University of Ottawa, Ottawa, Canada;cSun Health Research Institute, Sun City, AZ, USA;dThe Burnham Institute, La Jolla, CA, USA
Abstract:
Keywords:Alzheimer's disease   Cholesterol retention   Nuclear receptors   β  - and γ  -secretases     production
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