神经母细胞瘤57例临床分析

目的：讨论小儿神经母细胞瘤（NB）诊断、治疗与预后特点。方法：分析1994－1999年间收治小儿NB57例，以骨髓细胞形态学、X线、B超、CT及病理检查确诊。结果：57例男性39例，女性18例，各年龄段均可发病，5岁以下尤甚。临床以不规则发热、贫血、腹痛、腹部肿块为主要表现。NB好发于腹部，其次为后纵隔。确诊后49例予Apec方案化疗，其后手术。结论：骨髓细胞形态学和X线检查是诊断X线检查是诊断NB的较好方法，B超、CT可提高肿瘤检出率。NB经确诊首次化疗效果明显，其后延期手术。血清LDH明显增高化疗敏感性差，提示预后差。

Diagnosis and treatment of 57 cases of neuroblastomas

Objective: To discuss the diagnosis, treatment and prognosis of childrens' neuroblastoma (NB). Methods: We have analysed 57 cases NB including 39 boys and 18 girls from 1994-1997 diagnosed by marrow morphology , X- ray, B ultrasonic and pathology. Results: NB had be seen in all ages especially less than 5 year old. Its clinic feature was irregular fever, anemia, mass and pain in abdomen. NB had always been seen in abdomen and posterior mediastinum. After diagnosed, 49 cases of NB had been treated with AOPEC chemotheraputic method then operation. Conclusion: Marrow morphology and X-ray were good methods for diagnosis of NB, B ultrasonic and CT can improve positive incidence. The initial chemotheraputic may attain good effect and supply a good chance for subsequently operation. The high LDH concentration ingerred a bad prognosis.