| 8-(N,N-二乙铵)-n-辛基-3,4,5-三甲氧基苯甲酸酯对谷氨酸诱导神经细胞DNA损伤的影响 |
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| 引用本文： | 徐昌盛,肖继皋. 8-(N,N-二乙铵)-n-辛基-3,4,5-三甲氧基苯甲酸酯对谷氨酸诱导神经细胞DNA损伤的影响[J]. 中国生化药物杂志, 2002, 23(2): 64-66 |
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| 作者姓名： | 徐昌盛 肖继皋 |
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| 作者单位： | 1. 东南大学附属中大医院急诊科,江苏,南京,210009
2. 南京医科大学药理学教研室,江苏南京210029 |
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| 摘 要： | 目的研究 8 (N ,N 二乙铵 ) n 辛基 3,4 ,5 三甲氧基苯甲酸酯 (TMB 8)对谷氨酸诱导神经细胞DNA损伤的影响。方法用谷氨酸诱导培养的大鼠皮层神经细胞DNA断裂 ,观察TMB 8对神经细胞DNA断裂和线粒体功能的影响。结果TMB 8能明显减轻谷氨酸诱导的大鼠皮层神经细胞DNA断裂并能改善线粒体功能。结论TMB 8具有抑制神经细胞DNA损伤的作用 ,其机制可能与其降低细胞内游离钙、改善线粒体功能和减轻谷氨酸的氧化毒性有关
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| 关 键 词： | 神经细胞 8(N,N二乙铵)n辛基3,4,5三甲基苯甲酸酯 谷氨酸 DNA损伤 线粒体 |
| 文章编号： | 1005-1678(2002)02-0064-03 |
| 修稿时间： | 2001-05-28 |
Effect of 8-(N, N-diethylamino)octyl 3,4,5-trimethoxybenzoate on neuron DNA injury induced by glutamate |
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| DNA injury induced by glutamate XU Chang sheng ,XIAO Ji gao. Effect of 8-(N, N-diethylamino)octyl 3,4,5-trimethoxybenzoate on neuron DNA injury induced by glutamate[J]. Chinese Journal of Biochemical Pharmaceutics, 2002, 23(2): 64-66 |
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| Authors: | DNA injury induced by glutamate XU Chang sheng XIAO Ji gao |
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| Affiliation: | DNA injury induced by glutamate XU Chang sheng 1,XIAO Ji gao 2 |
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| Abstract: | PurposeThe aim is to investigate the effect of 8 ( N,N diethylamino)octyl 3,4,5 trimethoxybenzoate on neuron DNA injury.MethodsDNA injury of cultured cortical neuron induced by glutamate was used to observe the effect of TMB 8 on DNA fragment and mitochondrial function.ResultsTMB 8 could obviously inhibit neuron DNA fragment and improve mitochondrial function.ConclusionTMB 8 can inhibit neuron DNA injury through decreasing [Ca 2 ]i.improving mitochondrial function and reducing glutamate oxidative toxicity |
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| Keywords: | neuron TMB 8 glutamate DNA injury mitochondrial |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ |
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