卵巢早衰影响因素病例对照研究的相关性分析

目的探讨卵巢早衰（premature ovary failure，POF）发病的可能危险因素，旨在找出卵巢早衰发病的高危因素，为卵巢早衰的预防提供科学依据，为进一步病因研究提供线索。方法采用1：1配比的病例对照研究方法。抽取POF组150例，健康对照组150例，资料收集后，对每一变量进行定义、赋值，使用Excel建立数据库，采用单因素和多因素的条件Logistic回归分析性研究。结果单因素Logistic回归分析显示，婚姻状况，人工流产次数，心情，饮酒，吸烟等12个变量与POF的发生有关，经多因素Logistic回归分析后显示，婚姻状况（OR=5．753），人工流产次数（OR=2．076）。吸烟（OR=3．002），心情（OR=0．164），蔬菜摄入频率（OR=0．341），腮腺炎（OR=11．460）7个变量与POF仍有关联。结论POF的发病与生活方式，行为习惯，环境，医源性和感染有关。其中婚姻状况，人工流产次数，心情．饮酒，腮腺炎病史，蔬菜摄入频率是POF发生的主要影响因素。

Analysis of the Factors Related to the Development of Premature Ovarian Failure

Objective To analyze the potential factors related to the development of premature ovarian failure （POF）, and provide theoretic foundation of its prophylaxis. Method The data of each case was collected and analyzed by regressional analysis in POF group （n=150） and control group （n=150）. Result There are 12 factors showed relationship with POF by the single-factor conditional logistic regression analysis, such as marriage, the times of induced abortion, mood, alcohol abuse and smoking etc; there are 7 factors showed relationship with POF by muhivatiate conditional logistic regression analysis, such as marriage （OR=5.753）, the times of induced abortion （0R=2.076）, smoking （OR=3.002）, mood （OR=0.164）, frequency of eating vegetable （OR=0.341） and parotitis （OR=11.460）. Conclusion The etiology of POF has relationship with life style, behavior, environment, iatrogenic and infection. Among these, the marriage, number of induced abortion, mood, drinking, parotitis and intake of vegetable, were the main possible cause of POF.