广州市甲型H1N1流感病例密切接触者调查及医学观察结果分析

目的对广州市甲型H1N1流感病例密切接触者进行调查,并对隔离医学观察情况进行分析,为制定甲型H1N1流感防控措施提供科学依据。方法对确诊病例进行流行病学调查,确定密切接触者名单并对其进行追踪调查,采取定点医院和定点宾馆集中隔离医学观察的方法对密切接触者进行隔离观察,出现症状者采集咽拭子用real-time RT-PCR方法检测甲型H1N1流感病毒核酸。结果对223例密切接触者进行调查和观察,对其中23例出现症状者进行排查,及时发现3例甲型H1N1流感病例,其余220例均顺利解除隔离。在入境检疫时发现4例输入病例,其密切接触者104人,未发现甲型H1N1流感病例;在自行前往医院就诊时发现2例输入病例,其密切接触者共60人,发现了3例病例。密切接触者追踪调查与集中隔离时发现的3例病例,其密切接触者59人未发现甲型H1N1流感病例。结论对密切接触者进行调查和隔离医学观察是及时发现续发病例,防止疫情进一步传播和扩散的有效措施,病例不同发现方式影响密切接触者的转归。

Management and Analysis of H1N1 Close Contacts in Guangzhou City

Objective To analyze the situations of quarantine and management among H1N1 close contacts in Guangzhou city,in order to provide the scientific basis for the prevention and control of H1N1.Methods Close contacts are managed in fixed hospitals and hotels for medical observation.Real-time RT-PCR was used to detect type A H1N1 influenza virus nucleic acid in the throat swabs which were collected in the close contacts who had influenza-like symptoms.Results 223 cases of close contacts were investigated and observed. 3 cases of H1N1 positive were found out of 23 cases of close contacts had influenza-like symptoms. The other 220 cases were desegregate. 4 H1N1 imported cases were found in quarantined immigrants, and 104 cases of those with close contacts were H1N1 negative. 2 H1N1 imported cases were found in the people who went to hospital themselves, and 3 H1N1 positive cases were found out of 60 cases of those with close contacts. And 59 individuals who had close contacts with these 3 cases were H1N1 negative. Conclusion Monitoring the people who have close contacts with the H1N1 patients and finding out infected individuals are the effective measures to control spreading H1N1 influenza.