老年慢性肺心病患者血小板活性与高敏C反应蛋白的关系

目的探讨老年慢性肺心病患者血小板活化标志物PAC-1、CD62p的变化与高敏C反应蛋白（hs-CRP）的关系。方法用三色全血流式细胞术测定36例老年慢性肺心病患者外周血中血小板PAC-1、CD62p的表达水平,采用免疫比浊法测定hs-CRP,并与28例老年健康对照者及28例非老年健康对照者比较。结果老年慢性肺心病组PAC-1、CD62p、hs-CRP均明显高于老年健康对照组及非老年健康对照组（均P〈0.001）。老年健康对照组PAC-1、CD62p阳性表达率亦高于非老年健康对照组（P〈0.05）。老年慢性肺心病患者PAC-1、CD62的变化与hs-CRP呈正相关。结论老年慢性肺心病患者血小板明显活化,其活化程度与hs-CRP关系密切。

The Correlation between Platelet Activation and hs-CRP in Elderly Patients with Chronic Cor Pulmonale Pulmonary Heart Disease

Objective To investigate the relationship among PAC-1 CD62p in platelet activation marker and high-sensitivity C-reactive Protein （hs-CRP） in patients with chronic cor pulmonale. Methods Subjects were divided into groups （36 elderly patients with chronic cor pulmonale, 28 cases of healthy elderly subjects and 28 cases of healthy non-elderly subjects）. Positive rates of PAC-1 and CD62p were measured with tricolor flow cytometry. Hs-CRP levels were measured by nephelometry and turbidimetry in patients and normal controls. Results Compared with healthy elderly group and healthy non-elderly group, the expressions of both PAC-1, CD62p and hs-CRP increased significantly in patients with chronic cor pulmonale （all P〈0.001 ）. The levels of both PAC-1 and CD62p in healthy elderly subjects were statistically higher than that in healthy non-elderly subjects （P〈0.05）. There is a positive correlation between the PAC-1, CD62p in elderly patients with chronic cor pulmonale and hs-CRP. Conclusion The platelet in elderly patients with chronic cot pulmonale is at the over activated state, and there is a correlation between activated platelet and hs-CRP.