广州市18岁以下儿童青少年血脂水平的正常参考值调查

目的了解广州市18岁以下儿童青少年血脂水平，为该群体提供血脂水平正常参考值范围。方法采用多阶段随机抽样，抽取广州市区1390例（男／女=701／689）18岁以下人群，根据年龄（每3岁为一年龄段）及性别分为12组（0～岁男女组，3～岁男女组，6～岁男女组，9～岁男女组。12．岁男女组，15～18岁男女组），采集空腹静脉血，应用罗氏Integra400plus全自动生化仪，酶法测定总胆固醇（TC）、高密度脂蛋白胆固醇（HDL—C）、低密度脂蛋白胆固醇（LDL-C）、甘油三酯（TG），采用美国儿童青少年国家胆固醇教育计划（NCEP）推荐的取TC及LDL—C第75及第90百分位点作为临界脂蛋白水平及高脂蛋白浓度标准，并取TG第90百分位点作为高甘油三酯血症浓度，取HDL—C第5百分位点作为低高密度脂蛋白浓度。建立广州地区儿童血脂正常参考值。结果0～岁组、3～岁组男女组间的血脂4项浓度无统计学差异；6～岁性别组间中，HDL-C男性高于女性，LDL—C及TG女性高于男性；9～岁性别组间中，HDL—C男性高于女性，LDL—C女性高于男性；12～岁性别组间，TC和LDL—C女性高于男性；15～18岁性别组间中，HDL-C女性高于男性。结论通过对1390名广州市18岁以下儿童青少年的血脂调查，为建立广州地区不同年龄性别儿童青少年的血脂正常值提供了数据，确立了临界高胆固醇和高胆固醇血症浓度、高甘油三酯血症浓度和低高密度脂蛋白浓度。

Investigation of Serum Lipid Levels in Adolescents Under 18 Years Old in Guangzhou Area

Objective This study aimed to establish normal value of serum lipid level in adolescents under 18 years old in Cuangzhou area. Methods A total of 1390（male/female=701/689） healthy adolescents were chosen randomly, all come from Cuangzbou city. They were divided into 12 groups according to their gender and age （0- years old boys and girls; 3-years old boys and girls; 6- years old boys and girls; 9-years old boys and girls; 12- years old boys and girls; 15-18years old boys and girls; ）. Total cholesterol （TC）, triglyceride （TG）, high density lipoprotein-cholesterol （HDL-C） and low density lipoprotein-cholesterol （LDL-C） were detected by Integra 4000 plus automatic biochemical analyzer.The 75th and 90th percentiles of TC and LDL-C levels were adopted as the borderline and high of hypercholesterolemia.The 90th percentile of TG was served as the cut-off of hypertriglyceridemia. And the 5th of HDL-C acted as the lower limit to establish the criteria of dyslipidemia in Guangzhou adolescents. Results There was no statistical significance between males and females in 0- years and 3- years old groups of their TC, TG, HDL- C and LDL-C levels. In 6-years old group, HDL-C level in males was higher than that in females;LDL-C and TG levels in females were higher than those in males. In 9-years old group, HDL-C level in males was higher than that females; LDL-C level in females was higher than that in males. In 12- years old group, TC and LDL-C levels in females were both higher than those in males. In 15-18 years old group, HDL-C level in females was higher than that in males. Conclusions According to this investigation, data to establish criteria of serum lipid values in adolescents in Guangzhou are obtained.Age and sex have been analyzed. Borderline and high of TC and LDL-C levels have been defined. Cut-off of hypertriglyceridemia and hypohigh density lipoprotein cholesterolemia have also been established.