颅脑损伤患者血浆NPY及CGRP检测的临床意义

目的探讨血浆神经肽Y（NPY）和降钙素基因相关肽（CGRP）水平在不同程度颅脑外伤患者中的临床意义。方法采用放射免疫方法（RIA）对91例依据GCS评分法分为轻度、中度和重度的颅脑损伤患者及35例正常对照组的NPY、CGRP和ET-1水平进行检测。结果轻、中、重三组颅脑损伤患者血浆NPY水平分别为（119.6±20.3）ng/L、（127.8±25.5）ng/L和（146.2±30.5）ng/L,显著高于正常对照组（65.2±13.2）ng/L,差异有统计学意义（P〈0.01）。轻、中度患者血浆CGRP含量分别为（54.3±5.6）ng/L、（57.5±7.4）ng/L,显著高于正常对照组（41.8±6.8）ng/L,差异有统计学意义（P〈0.01）;而重度患者组的CGRP水平（44.6±5.3）ng/L与对照组（41.8±6.8）ng/L间差异无统计学意义（P〉0.05）。结论血浆NPY及CGRP水平与不同程度颅脑损伤患者的病情密切相关,并对患者预后的判定具有一定的临床参考价值。

The Clinical Significance of Plasma NPY and CGRP Levels in Patients with Traumatic Brain Injury

Objectives To study the neuropeptide Y（NPY） and ealcitonin gene-related peptide（CGRP） levels in patients with traumatic brain injury of different severity. Methods 91 patients with traumatic brain injury were divided into three group on the basis of GCS：mild group, moderate group and severe group. The plasma NPY and CGRP levels in these patients and 35 controls were determined with RIA. Results ①The plasma NPY levels in patients with mild, moderate and severe traumatic brain injury were （119.6±20.3） ng/L, （127.8±25.5） ng/L and （146.2±30.5） ng/L, respectively, which were significantly higher than that in control group （65.2±13.2） ng/L （P〈 0.01 ）.②The plasma CGRP levels in patients of mild and moderate brain injury were （54.3±5.6） ng/L and （57.5±7.4） ng/L, respectively, which were found significantly higher than those in control （41.8±6.8） ng/L （P〈0.01）, while no significant differences were found between that in severe （44.6±5.3） ng/L and control group （41.8±6.8） ng/L （P〉0.05）. Conclusion The plasma NPY and CGRP levels in the patients with traumatic brain injury are correlated with the severity of the damage, and may have prognostic value.