乙型肝炎纤维蛋白原定量的临床应用

目的通过测定乙肝患者血浆纤维蛋白原的变化，探讨纤维蛋白原对各型乙型肝炎的诊断价值。方法应用全自动血凝仪以Clauss法分别测定50例急性肝炎，48例慢性活动性肝炎，11例重型肝炎，18例肝硬化及66例正常对照者的血浆纤维蛋白原的含量。并比较各型乙型肝炎与正常对照的纤维蛋白原的水平差异。结果急性肝炎组与对照组间纤维蛋白原的含量差异无统计学意义（P〉0．05），慢性活动性肝炎、肝硬化及重型肝炎与对照组比较差异有统计学意义（P〈0．01）。结论血浆纤维蛋白原检测能反映乙肝患者肝功能受损的凝血变化，对预后的判断有良好的临床应用价值。

Clinical Application of Quantification of Plasma Fibrinogen in Hepatitis B Patients

Objective To study the changes of plasma fibrinogen in patients with hepatitis B. Method Plasma fibrinogen were determined by Clauss Assay which was examined by automatic coagulation analyzer. The experiment included 50 acute hepatitis patients, 48 chronic active hepatitis patients, 11 severe hepatitis patients, 18 hepatic cirrhosis patients and 66 normal controls. The Results of plasma fibrinogen were compared with each abnormal groups and normal controls. Result The value of plasma fibrinogen in acute hepatitis group have no significant difference when compared with control group （P〉0.05）. The fihrinogen levels in chronic active hepatitis, Liver Cirrhosis and Severe Hepatitis were significantly different from control group （P〈0.01）. Conclusion Fibrinogcn level can reflect the degree of damage of the live function and coagulation function, and is clinically useful for the prognosis in patients with hepatitis B.