Synthesis and antioxidative properties of novel thiazolidinedione/imidazolidinedione compounds as retinoids |
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| Authors: | Dundar B Bozdag-Dundar O Can-Eke B Coban T Iscan M Buyukbingol E |
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| Affiliation: | Department of Pharmaceutical Chemistry, Ankara University, Faculty of Pharmacy, Tandogan, Ankara, Turkey. |
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| Abstract: | The general term "retinoids" refers to both naturally occurring as well as synthetic compounds which exhibit biological activity similar to vitamin A (retinol). Vitamin A and its two metabolites, retinaldehyde and retinoic acid, are fat-soluble unsaturated isoprenoids necessary for the growth, differentiation and maintenance of epithelial tissues. In this study, we have synthesized thiazolidinedione/imidazolidinedione compounds as retinoids. Their in vitro effects on rat liver microsomal NADPH-dependent lipid peroxidation (LP) levels and superoxide anion formation were determined. |
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