多巴胺受体激动剂对丙烯酰胺诱导大鼠神经损伤的影响

目的 研究丙烯酰胺对大鼠中枢神经系统神经递质多巴胺含量的影响以及多巴胺受体激动剂对丙烯酰胺引起的神经损伤的影响,探讨丙烯酰胺的神经损伤机制以及确定多巴胺受体激动剂对丙烯酰胺引起的神经损伤是否具有保护作用.方法 SD大鼠染毒组腹腔注射丙烯酰胺4周,每周5次(30 mg/kg);溴隐亭给药组在腹腔注射丙烯酰胺的同时灌胃给予多巴胺受体激动剂溴隐亭(低剂量组按1.25 mg/kg给药,高剂量组按2.5 mg/kg给药);正常对照组腹腔注射等量生理盐水.每周给药第6天和第7天对大鼠进行感觉神经功能测定以及自主性行为观察.给药结束后,测定大鼠中枢神经系统多巴胺、肌酸激酶(CK)以及Na -K -ATP酶的含量.结果 染毒组大鼠体重呈下降趋势,与其他3组大鼠体重均存在明显差异,染毒组热反应灵敏度也较差,给药组无论低剂量或高剂量组,热反应灵敏度均比染毒组有所改善.此外,染毒组CK、Na -K -ATP酶以及多巴胺的含量均比正常对照组明显减少,给药组各指标也比阳性对照组有所升高.结论 多巴胺受体激动剂溴隐亭对丙烯酰胺诱导的大鼠神经损伤有一定的保护作用.

Effect of dopamine agonists on nerve injury caused by acrylamide in rats

Objective To explore the protective effects of dopamine agonists on nerve injury induced by acrylamide in rats.Methods Exposed SD rats were injected intraperitoneally acrylamide(30 mg/kg),5 times a week for 4 weeks;the rats in intervention group were intragastrically administrated a dopamine agonist,bromcriptine(1.25 mg/kg and 2.5 mg/kg)simultaneously with the injection of acrylamide;the control rats were only injected intraperitoneally with normal saline.The function test of sensory nerve and independent b...