一种抗转移层粘连蛋白核心三糖的合成

本文完成了一种具有潜在转移活性的层粘连蛋白核心三糖β—D—Gal-（1→4）-β—D—GlcpNAc-（1→6）-α-D—Manp—OMe的合成。以2-碘代叠氮乳糖为供体采用“叠氮碘糖基化”反应一步完成了2-脱氧-2-氨基乳糖结构及1，2-反式-氨基乳糖糖苷键的立体选择性构建。这种方法能简易、高效地合成含氨基乳糖的寡糖，较好地避免了直接使用活性较差的2-氨基糖衍生物构建氨基乳糖模块。

Facile synthesis of a core trisaccharide of laminin as a potential metastatic antagonist

A core trisaccharide of laminin, β-D-Gal-（1→4）-β-D-GlcpNAc-（1→6）-α-D-Manp-OMe, with potential anti-rumor metastatic activity was designed and prepared. 2-Iodoglactosyl azide was used as the donor to construct 2-N-acetamido-2-deoxylactosyl moiety through an azidoiodo-glycosylation reaction. Simultaneously, 1, 2-trans-β-glycosic bond was formed stereoselectively in one step with a moderate yield. This novel procedure avoided the use of 2-amino-2-deoxyglucose as both donor and acceptor.