比索洛尔治疗原发性高血压患者的疗效观察

目的：评价比索洛尔治疗原发性高血压患者诊室血压的安全性和疗效。方法：36例初诊的轻、中度原发性高血压患者接受比索洛尔治疗4周，检测治疗前后诊室血压、动态血压及生化指标的变化，并设有安慰剂对照组36例。结果：比索洛尔组显效10例，有效14例；对照组显效4例，有效10例，2组疗效差异有统计学意义（P〈0．05）。诊室血压、心率、24h血压、白天血压、夜间血压、最大血压和最小舒张压均有降低（P〈0．05），收缩压与舒张压的谷／峰比值分别为53％和69％。治疗前后生化指标变化差别无统计学意义。结论：比索洛尔是治疗原发性高血压安全有效的药物．对糖、脂代谢无明显影响。

Efficacy of Bisoprolol on Clinical Blood Pressure and Ambulatory Blood Pressure in Patients with Essential Hypertension

Objective: To evaluate the safety and efficiency of bisoprolol in treating patients with essential hypertension. Methods: Clinical blood pressure(BP), ambulatory blood pressure monitoring and biochemical markers were observed in thirty-six patients who were mild and severe preliminary diagnosis essential hypertension before and after treating with bisoprolol four weeks and compared with the placebo control group. Results: Ten patients had evident effect and forteen patients had effect in the bisoprolol group, correspondingly,there was four patients and ten patients in the control group.The difference had statistical significance(P< 0.05). Clinical BP, heart rate, 24 h BP, daily BP, night BP, maximal BP, minimal diastolic BP all decreased(P < 0.05). T/P ratio of systolic blood pressure and diastolic blood pressure was 53% and 69% respectively, the biochemical markers were not statistically significant before and after treatment. Conclusion: Bisoprolol is not only effective and safe, but also no any influence on metabolism of lipids and glucose in treating patients with essential hypertension.