Inhibition of Aurora kinases enhances chemosensitivity to temozolomide and causes radiosensitization in glioblastoma cells期刊界 All Journals 搜尽天下杂志传播学术成果专业期刊搜索期刊信息化学术搜索

Inhibition of Aurora kinases enhances chemosensitivity to temozolomide and causes radiosensitization in glioblastoma cells

Authors:	Kleiton?Silva?Borges author-information" > author-information__contact u-icon-before" > mailto:ksborges@usp.br" title=" ksborges@usp.br" itemprop=" email" data-track=" click" data-track-action=" Email author" data-track-label=" " >Email author,Angel?Maurício?Castro-Gamero,Daniel?Antunes?Moreno,Vanessa?da?Silva Silveira,Maria?Sol?Brassesco,Rosane?Gomes?de?Paula Queiroz,Harley?Francisco?de?Oliveira,Carlos?Gilberto?Carlotti Suffix" >Jr.,Carlos?Alberto?Scrideli,Luiz?Gonzaga?Tone

Affiliation:	1.Department of Genetics, School of Medicine of Ribeir?o Preto,University of S?o Paulo (USP),Ribeir?o Preto,Brazil;2.Department of Pediatrics, School of Medicine of Ribeir?o Preto,University of S?o Paulo (USP),Ribeir?o Preto,Brazil;3.Department of Clinical Medicine, School of Medicine of Ribeir?o Preto,University of S?o Paulo (USP),Ribeir?o Preto,Brazil;4.Department of Surgery and Anatomy, School of Medicine of Ribeir?o Preto,University of S?o Paulo (USP),Ribeir?o Preto,Brazil

Abstract:	Background Glioblastoma remains one of the most devastating human malignancies, and despite therapeutic advances, there are no drugs that significantly improve the patient survival. Altered expression of the Aurora kinases was found in different malignancies, and their inhibition has been studied in cancer therapy. In this study, we analyzed the expression of Aurora A and Aurora B in glioblastoma samples and also analyzed whether the effects of Aurora kinase inhibition were associated with temozolomide or not on cell lines and primary cultures of glioblastoma.

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