Arterial Stiffness and Peripheral and Central Blood Pressure in Patients With Sickle Cell Disease |
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| Authors: | Maria Pikilidou MD MSc PhD Maria Yavropoulou MD PhD Maria Antoniou MD Eleftherios Papakonstantinou MD Despoina Pantelidou MD Panagiota Chalkia MD Peter Nilsson MD PhD John Yovos MD PhD Pantelis Zebekakis MD PhD |
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| Affiliation: | 1. Hypertension Excellence Center, AHEPA University Hospital, Thessaloniki, Greece;2. Division of Clinical and Molecular Endocrinology, AHEPA University Hospital, Thessaloniki, Greece;3. Division of Hematology and Thalassemia Unit, 1st Department of Internal Medicine, AHEPA University Hospital, Thessaloniki, Greece;4. Department of Clinical Sciences, Lund University, Malmo, Sweden |
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| Abstract: | Blood pressure (BP) in patients with sickle cell disease (SCD) has been reported to be lower than in persons in the general population. Data on arterial stiffness, which is an important risk factor for the progression of BP, are inconclusive for this patient population. Forty‐five adult patients with SCD and 40 controls matched for sex, age, and body mass index were studied. Brachial systolic BP (SBP) and diastolic BP (DBP) were significantly lower in the patient group (SBP 115.1±13.8 mm Hg vs 121.9±11.3 mm Hg and DBP 68.5±8.0 mm Hg vs 80.6±9.1 mm Hg, P<.05, respectively). Augmentation index (AIx), however, was significantly higher in SCD patients compared with healthy controls (24.9±9.6 for patients vs 12.4±10.8 for controls, P<.001), while carotid femoral pulse wave velocity was comparable between the two groups. The study shows that mechanisms other than arterial elasticity are involved in the low BP phenotype of patients with SCD. |
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